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Gene Review

Cia25  -  Collagen induced arthritis QTL 25

Rattus norvegicus

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High impact information on Cia25

  • Cia25 regulates MAS and disease severity during the mid-to-late stages of the disease course and may be accounted for by Ncf1 polymorphisms [1].
  • The homozygous DA genotype at Cia25 was associated with a 45% higher median arthritis score in females [1].
  • RESULTS: A new female-specific arthritis-severity recessive locus was identified on rat chromosome 12 (Cia25), with a maximum effect observed on day 28 (logarithm of odds [LOD] 4.7) [1].

Other interactions of Cia25

  • Sequencing analyses of the Cia25 candidate gene Ncf1 revealed polymorphisms between DA and ACI [1].


  1. Identification of two novel female-specific non-major histocompatibility complex loci regulating collagen-induced arthritis severity and chronicity, and evidence of epistasis. Meng, H.C., Griffiths, M.M., Remmers, E.F., Kawahito, Y., Li, W., Neisa, R., Cannon, G.W., Wilder, R.L., Gulko, P.S. Arthritis Rheum. (2004) [Pubmed]
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