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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Ctr1B  -  Copper transporter 1B

Drosophila melanogaster

Synonyms: CG7459, Dmel\CG7459, ctr1B
 
 
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High impact information on Ctr1B

  • Here we describe a novel and seemingly paradoxical role for MTF-1 in Drosophila in that it also mediates transcriptional activation of Ctr1B, a copper importer, upon copper depletion [1].
  • Significantly, Cu induced Ctr1B gene expression, and this could be prevented by suppressing MTF-1, suggesting that Ctr1B might be involved in Cu detoxification [2].

References

  1. Metal-responsive transcription factor (MTF-1) handles both extremes, copper load and copper starvation, by activating different genes. Selvaraj, A., Balamurugan, K., Yepiskoposyan, H., Zhou, H., Egli, D., Georgiev, O., Thiele, D.J., Schaffner, W. Genes Dev. (2005) [Pubmed]
  2. Copper homoeostasis in Drosophila melanogaster S2 cells. Southon, A., Burke, R., Norgate, M., Batterham, P., Camakaris, J. Biochem. J. (2004) [Pubmed]
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