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Gene Review

IGF1R  -  insulin-like growth factor 1 receptor

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High impact information on IGF1R

  • IGF-1 stimulates the IGF-1 receptor (IGF1R) and downstream signaling pathways, including extracellular signal-regulated kinase (ERK) and phosphoinositol-3 kinase (PI3K) [1].
  • There was no significant difference, however, in the adrenal expression of the cyclin-kinase inhibitory proteins (p16ink or p21Cip) or in the IGF system (IGF-II, IGFBP-2 or IGF1R) mRNA between metyrapone- and vehicle-infused [2].


  1. Extracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes. Sundgren, N.C., Giraud, G.D., Schultz, J.M., Lasarev, M.R., Stork, P.J., Thornburg, K.L. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
  2. Metyrapone infusion stimulates adrenal growth without activating the cell cycle or the IGF system in the late gestation fetal sheep. Warnes, K.E., McMillen, I.C., Robinson, J.S., Coulter, C.L. Endocr. Res. (2004) [Pubmed]
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