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Gene Review

IGF1  -  insulin-like growth factor 1 (somatomedin C)

Ovis aries

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Disease relevance of IGF1

  • This study was designed to determine the potential of IGF-1 as a neuronal rescue agent after cerebral ischemia [1].
  • Decreased serum insulin-like growth factor-I associated with growth failure in newborn lambs with experimental cyanotic heart disease [2].
  • Insulin-like growth factor (IGF-1) markedly increases myelination and glial numbers in white matter after ischemia in near-term fetal sheep; however, it is unclear whether this is due to reduced cell loss or increased secondary proliferation [3].
  • In conclusion, IGF-1 can prevent delayed, postischemic oligodendrocyte cell loss and associated demyelination [4].
  • IUGR fetuses received daily intraamniotic injections of saline or IGF-1 (20 microg/d) from 120 to 130 days [5].

High impact information on IGF1


Biological context of IGF1


Anatomical context of IGF1


Associations of IGF1 with chemical compounds


Regulatory relationships of IGF1


Other interactions of IGF1


Analytical, diagnostic and therapeutic context of IGF1


  1. Insulin-like growth factor-1 is a potent neuronal rescue agent after hypoxic-ischemic injury in fetal lambs. Johnston, B.M., Mallard, E.C., Williams, C.E., Gluckman, P.D. J. Clin. Invest. (1996) [Pubmed]
  2. Decreased serum insulin-like growth factor-I associated with growth failure in newborn lambs with experimental cyanotic heart disease. Bernstein, D., Jasper, J.R., Rosenfeld, R.G., Hintz, R.L. J. Clin. Invest. (1992) [Pubmed]
  3. Insulin-like growth factor (IGF)-1 suppresses oligodendrocyte caspase-3 activation and increases glial proliferation after ischemia in near-term fetal sheep. Cao, Y., Gunn, A.J., Bennet, L., Wu, D., George, S., Gluckman, P.D., Shao, X.M., Guan, J. J. Cereb. Blood Flow Metab. (2003) [Pubmed]
  4. Insulin-like growth factor-1 reduces postischemic white matter injury in fetal sheep. Guan, J., Bennet, L., George, S., Wu, D., Waldvogel, H.J., Gluckman, P.D., Faull, R.L., Crosier, P.S., Gunn, A.J. J. Cereb. Blood Flow Metab. (2001) [Pubmed]
  5. Effects of intrauterine growth restriction and intraamniotic insulin-like growth factor-I treatment on blood and amniotic fluid concentrations and on fetal gut uptake of amino acids in late-gestation ovine fetuses. Bloomfield, F.H., van Zijl, P.L., Bauer, M.K., Harding, J.E. J. Pediatr. Gastroenterol. Nutr. (2002) [Pubmed]
  6. Developmental patterns of insulin-like growth factor-I and -II synthesis and regulation in rat fibroblasts. Adams, S.O., Nissley, S.P., Handwerger, S., Rechler, M.M. Nature (1983) [Pubmed]
  7. Overexpression of ovine insulin-like growth factor-I stimulates autonomous autocrine or paracrine growth in bovine mammary-derived epithelial cells. Romagnolo, D., Akers, R.M., Wong, E.A., Boyle, P.L., McFadden, T.B., Turner, J.D. Mol. Endocrinol. (1992) [Pubmed]
  8. The circulating molecular weight forms of infused recombinant insulin-like growth factor-I and effects on glucose and fat metabolism in lambs. Douglas, R.G., Breier, B.H., Gallaher, B.W., Koea, J.B., Shaw, J.H., Gluckman, P.D. Diabetologia (1991) [Pubmed]
  9. Characterization of multiple transcription initiation sites of the ovine insulin-like growth factor-I gene and expression profiles of three alternatively spliced transcripts. Ohlsen, S.M., Dean, D.M., Wong, E.A. DNA Cell Biol. (1993) [Pubmed]
  10. A BglII RFLP at the ovine locus for insulin-like growth factor 1 (IGF1). Demmer, J., Galloway, S.M. Anim. Genet. (1993) [Pubmed]
  11. Insulin-like growth factor 1 alters feto-placental protein and carbohydrate metabolism in fetal sheep. Harding, J.E., Liu, L., Evans, P.C., Gluckman, P.D. Endocrinology (1994) [Pubmed]
  12. Pregnancy-specific alterations in the expression of the insulin-like growth factor system during early placental development in the ewe. Reynolds, T.S., Stevenson, K.R., Wathes, D.C. Endocrinology (1997) [Pubmed]
  13. Changes in insulin-like growth factor-I (IGF-I), IGF-II, and their binding proteins during growth and atresia of ovine ovarian follicles. Monget, P., Monniaux, D., Pisselet, C., Durand, P. Endocrinology (1993) [Pubmed]
  14. Localization of insulin-like growth factor-I (IGF-I) and -II messenger ribonucleic acid and type 1 IGF receptors in the ovine uterus during the estrous cycle and early pregnancy. Stevenson, K.R., Gilmour, R.S., Wathes, D.C. Endocrinology (1994) [Pubmed]
  15. Control of growth hormone receptor and insulin-like growth factor-I expression by cortisol in ovine fetal skeletal muscle. Li, J., Forhead, A.J., Dauncey, M.J., Gilmour, R.S., Fowden, A.L. J. Physiol. (Lond.) (2002) [Pubmed]
  16. PGE1 or PGE2 not LH regulates secretion of progesterone in vitro by the 88-90 day ovine corpus luteum of pregnancy. Weems, Y.S., Bridges, P.J., Tanaka, Y., Sasser, R.G., LeaMaster, B.R., Vincent, D.L., Weems, C.W. Prostaglandins (1997) [Pubmed]
  17. Photo-neuroendocrine control of seasonal cycles in body weight, pelage growth and reproduction: lessons from the HPD sheep model. Lincoln, G.A., Richardson, M. Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. (1998) [Pubmed]
  18. Synergistic effect of insulin-like growth factor-I administration on the protein-sparing effects of total parenteral nutrition in fasted lambs. Koea, J.B., Douglas, R.G., Breier, B.H., Shaw, J.H., Gluckman, P.D. Endocrinology (1992) [Pubmed]
  19. Regulation of insulin-like growth factor-I and progesterone synthesis by insulin and growth hormone in the ovine ovary. Wathes, D.C., Perks, C.M., Davis, A.J., Denning-Kendall, P.A. Biol. Reprod. (1995) [Pubmed]
  20. Growth hormone and amino acid supply interact synergistically to control insulin-like growth factor-I production and gene expression in cultured ovine hepatocytes. Wheelhouse, N.M., Stubbs, A.K., Lomax, M.A., MacRae, J.C., Hazlerigg, D.G. J. Endocrinol. (1999) [Pubmed]
  21. Extracellular signal-regulated kinase and phosphoinositol-3 kinase mediate IGF-1 induced proliferation of fetal sheep cardiomyocytes. Sundgren, N.C., Giraud, G.D., Schultz, J.M., Lasarev, M.R., Stork, P.J., Thornburg, K.L. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
  22. Sheep gene mapping: additional DNA markers included (CASB, CASK, LALBA, IGF-1 and AMH). Ghali, M.I., Saidi-Mehtar, N., Guerin, G. Anim. Genet. (1991) [Pubmed]
  23. Maternal nutrient restriction during early to mid gestation up-regulates cardiac insulin-like growth factor (IGF) receptors associated with enlarged ventricular size in fetal sheep. Dong, F., Ford, S.P., Fang, C.X., Nijland, M.J., Nathanielsz, P.W., Ren, J. Growth Horm. IGF Res. (2005) [Pubmed]
  24. Regulation of gelatinase-A (MMP-2) production by ovine intervertebral disc nucleus pulposus cells grown in alginate bead culture by Transforming Growth Factor-beta(1)and insulin like growth factor-I. Pattison, S.T., Melrose, J., Ghosh, P., Taylor, T.K. Cell Biol. Int. (2001) [Pubmed]
  25. The ontogeny of hepatic growth hormone receptor and insulin-like growth factor I gene expression in the sheep fetus during late gestation: developmental regulation by cortisol. Li, J., Owens, J.A., Owens, P.C., Saunders, J.C., Fowden, A.L., Gilmour, R.S. Endocrinology (1996) [Pubmed]
  26. Improved wool production in transgenic sheep expressing insulin-like growth factor 1. Damak, S., Su, H., Jay, N.P., Bullock, D.W. Biotechnology (N.Y.) (1996) [Pubmed]
  27. Passive immunization against insulin-like growth factor-I does not inhibit growth hormone-stimulated growth of dwarf rats. Spencer, G.S., Hodgkinson, S.C., Bass, J.J. Endocrinology (1991) [Pubmed]
  28. Distribution of circulating insulin-like growth factor-I (IGF-I) into tissues. Hodgkinson, S.C., Spencer, G.S., Bass, J.J., Davis, S.R., Gluckman, P.D. Endocrinology (1991) [Pubmed]
  29. The measurement of insulin-like growth factor 1 in sheep plasma. Bruce, L.A., Atkinson, T., Hutchinson, J.S., Shakespear, R.A., MacRae, J.C. J. Endocrinol. (1991) [Pubmed]
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