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Gene Review: 

nppa  -  atrial natriuretic peptide

Takifugu rubripes

 
 
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High impact information on anp

  • The natriuretic peptide (NP) family is composed of three members: atrial, brain/ventricular and C-type NPs (ANP, BNP/VNP and CNP respectively) in tetrapods and teleostean fish, but only CNP in elasmobranch fish [1].
  • VNP has not been molecularly identified in mammals but its presence is suggested from physiological studies; heterologous fish VNP exhibited more potent vasorelaxant activity than homologous mammalian ANP in the isolated coronary artery of dogs [1].

References

  1. Four natriuretic peptides (ANP, BNP, VNP and CNP) coexist in the sturgeon: identification of BNP in fish lineage. Kawakoshi, A., Hyodo, S., Inoue, K., Kobayashi, Y., Takei, Y. J. Mol. Endocrinol. (2004) [Pubmed]
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