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Gene Review: 

ptprc  -  CD45

Takifugu rubripes

 
 
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High impact information on PTPRc

  • The leukocyte common antigen (CD45) is a transmembrane protein tyrosine phosphatase expressed only in nucleated hematopoietic cells [1].
  • The Fugu CD45 gene has a similar exon/intron organization to that of mammals except in the 5' end where some exons are missing or fused together [1].
  • The Fugu CD45 cDNA sequence contains an open reading frame of 1,246 amino acids with a variable extracellular region as a result of the alternative splicing of two exons [1].

References

  1. Genomic structure and sequence of the leukocyte common antigen (CD45) from the pufferfish Fugu rubripes and comparison with its mammalian homologue. Díaz del Pozo, E., Beverley, P.C., Timón, M. Immunogenetics (2000) [Pubmed]
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