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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Leukocytes


Psychiatry related information on Leukocytes


High impact information on Leukocytes


Chemical compound and disease context of Leukocytes


Biological context of Leukocytes


Anatomical context of Leukocytes


Associations of Leukocytes with chemical compounds


Gene context of Leukocytes

  • Thus, fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators, performing both adhesive and chemotactic functions [35].
  • Increased leukocyte elastase activity in mice lacking secretory leukocyte protease inhibitor (SLPI) leads to impaired wound healing due to enhanced activity of TGFbeta and perhaps additional mechanisms [36].
  • The killer immunoglobulin-like receptors (KIRs) on NK cells regulate the inhibition and activation of NK-cell responses through recognition of human leukocyte antigen (HLA) class I molecules on target cells KIR and HLA loci are both highly polymorphic, and some HLA class I products bind and trigger cell-surface receptors specified by KIR genes [37].
  • Leukocytes bearing a C52F mutation showed increased membrane TNFR1 and reduced receptor cleavage following stimulation [38].
  • Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion [35].

Analytical, diagnostic and therapeutic context of Leukocytes

  • Our findings conclude that the interplay of fibrin fragments, leukocytes and VE-cadherin contribute to the pathogenesis of myocardial damage and reperfusion injury [39].
  • Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes [40].
  • We found that homophilic ligation of CD31 (ref. 4) on viable leukocytes promoted their active, temperature-dependent detachment under low shear, whereas such CD31-mediated detachment was disabled in apoptotic leukocytes, promoting tight binding and macrophage ingestion of dying cells [41].
  • During recent years clinical trials have shown that human leukocyte interferon (HuIFN-alpha) may be useful in the treatment of cancer, but very little has been done concerning the possible use of human fibroblast interferon (HuIFN-beta) [42].
  • The patient showed positive intracutaneous skin tests to his unfractionated seminal plasma and a Sephadex G100 fraction designated No. 3. This fraction was also passively transferable to a nonallergic volunteer and it stimulated histamine release from the patient's leukocytes [43].


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  20. Unsuspected osteomyelitis in diabetic foot ulcers. Diagnosis and monitoring by leukocyte scanning with indium in 111 oxyquinoline. Newman, L.G., Waller, J., Palestro, C.J., Schwartz, M., Klein, M.J., Hermann, G., Harrington, E., Harrington, M., Roman, S.H., Stagnaro-Green, A. JAMA (1991) [Pubmed]
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  28. Deficiency of enzymes catalyzing the biosynthesis of glycerol-ether lipids in Zellweger syndrome. A new category of metabolic disease involving the absence of peroxisomes. Datta, N.S., Wilson, G.N., Hajra, A.K. N. Engl. J. Med. (1984) [Pubmed]
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  31. Chemoattractant receptors on phagocytic cells. Snyderman, R., Pike, M.C. Annu. Rev. Immunol. (1984) [Pubmed]
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  36. Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Zhu, J., Nathan, C., Jin, W., Sim, D., Ashcroft, G.S., Wahl, S.M., Lacomis, L., Erdjument-Bromage, H., Tempst, P., Wright, C.D., Ding, A. Cell (2002) [Pubmed]
  37. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Martin, M.P., Gao, X., Lee, J.H., Nelson, G.W., Detels, R., Goedert, J.J., Buchbinder, S., Hoots, K., Vlahov, D., Trowsdale, J., Wilson, M., O'Brien, S.J., Carrington, M. Nat. Genet. (2002) [Pubmed]
  38. Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. McDermott, M.F., Aksentijevich, I., Galon, J., McDermott, E.M., Ogunkolade, B.W., Centola, M., Mansfield, E., Gadina, M., Karenko, L., Pettersson, T., McCarthy, J., Frucht, D.M., Aringer, M., Torosyan, Y., Teppo, A.M., Wilson, M., Karaarslan, H.M., Wan, Y., Todd, I., Wood, G., Schlimgen, R., Kumarajeewa, T.R., Cooper, S.M., Vella, J.P., Amos, C.I., Mulley, J., Quane, K.A., Molloy, M.G., Ranki, A., Powell, R.J., Hitman, G.A., O'Shea, J.J., Kastner, D.L. Cell (1999) [Pubmed]
  39. The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Petzelbauer, P., Zacharowski, P.A., Miyazaki, Y., Friedl, P., Wickenhauser, G., Castellino, F.J., Gröger, M., Wolff, K., Zacharowski, K. Nat. Med. (2005) [Pubmed]
  40. Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. Fawcett, J., Holness, C.L., Needham, L.A., Turley, H., Gatter, K.C., Mason, D.Y., Simmons, D.L. Nature (1992) [Pubmed]
  41. Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment. Brown, S., Heinisch, I., Ross, E., Shaw, K., Buckley, C.D., Savill, J. Nature (2002) [Pubmed]
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  43. Successful long-term immunotherapy for human seminal plasma anaphylaxis. Friedman, S.A., Bernstein, I.L., Enrione, M., Marcus, Z.H. JAMA (1984) [Pubmed]
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