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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Leukocytes

 
 
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Disease relevance of Leukocytes

 

Psychiatry related information on Leukocytes

 

High impact information on Leukocytes

 

Chemical compound and disease context of Leukocytes

 

Biological context of Leukocytes

 

Anatomical context of Leukocytes

 

Associations of Leukocytes with chemical compounds

 

Gene context of Leukocytes

  • Thus, fractalkine and CX3CR1 represent new types of leukocyte trafficking regulators, performing both adhesive and chemotactic functions [35].
  • Increased leukocyte elastase activity in mice lacking secretory leukocyte protease inhibitor (SLPI) leads to impaired wound healing due to enhanced activity of TGFbeta and perhaps additional mechanisms [36].
  • The killer immunoglobulin-like receptors (KIRs) on NK cells regulate the inhibition and activation of NK-cell responses through recognition of human leukocyte antigen (HLA) class I molecules on target cells KIR and HLA loci are both highly polymorphic, and some HLA class I products bind and trigger cell-surface receptors specified by KIR genes [37].
  • Leukocytes bearing a C52F mutation showed increased membrane TNFR1 and reduced receptor cleavage following stimulation [38].
  • Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion [35].
 

Analytical, diagnostic and therapeutic context of Leukocytes

  • Our findings conclude that the interplay of fibrin fragments, leukocytes and VE-cadherin contribute to the pathogenesis of myocardial damage and reperfusion injury [39].
  • Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes [40].
  • We found that homophilic ligation of CD31 (ref. 4) on viable leukocytes promoted their active, temperature-dependent detachment under low shear, whereas such CD31-mediated detachment was disabled in apoptotic leukocytes, promoting tight binding and macrophage ingestion of dying cells [41].
  • During recent years clinical trials have shown that human leukocyte interferon (HuIFN-alpha) may be useful in the treatment of cancer, but very little has been done concerning the possible use of human fibroblast interferon (HuIFN-beta) [42].
  • The patient showed positive intracutaneous skin tests to his unfractionated seminal plasma and a Sephadex G100 fraction designated No. 3. This fraction was also passively transferable to a nonallergic volunteer and it stimulated histamine release from the patient's leukocytes [43].

References

  1. Human leukocyte interferon and cimetidine for metastatic melanoma. Borgström, S., von Eyben, F.E., Flodgren, P., Axelsson, B., Sjögren, H.O. N. Engl. J. Med. (1982) [Pubmed]
  2. Organ-specific disease provoked by systemic autoimmunity. Kouskoff, V., Korganow, A.S., Duchatelle, V., Degott, C., Benoist, C., Mathis, D. Cell (1996) [Pubmed]
  3. Genetic basis of variable exon 9 skipping in cystic fibrosis transmembrane conductance regulator mRNA. Chu, C.S., Trapnell, B.C., Curristin, S., Cutting, G.R., Crystal, R.G. Nat. Genet. (1993) [Pubmed]
  4. Analysis of dystrophin expression after activation of myogenesis in amniocytes, chorionic-villus cells, and fibroblasts. A new method for diagnosing Duchenne's muscular dystrophy. Sancho, S., Mongini, T., Tanji, K., Tapscott, S.J., Walker, W.F., Weintraub, H., Miller, A.D., Miranda, A.F. N. Engl. J. Med. (1993) [Pubmed]
  5. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Palabrica, T., Lobb, R., Furie, B.C., Aronovitz, M., Benjamin, C., Hsu, Y.M., Sajer, S.A., Furie, B. Nature (1992) [Pubmed]
  6. Notch deficiency implicated in the pathogenesis of congenital disorder of glycosylation IIc. Ishikawa, H.O., Higashi, S., Ayukawa, T., Sasamura, T., Kitagawa, M., Harigaya, K., Aoki, K., Ishida, N., Sanai, Y., Matsuno, K. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  7. Effect of human OGG1 1245C-->G gene polymorphism on 8-hydroxy-2'-deoxyguanosine levels of leukocyte DNA among patients undergoing chronic hemodialysis. Tarng, D.C., Tsai, T.J., Chen, W.T., Liu, T.Y., Wei, Y.H. J. Am. Soc. Nephrol. (2001) [Pubmed]
  8. Fish consumption among healthy adults is associated with decreased levels of inflammatory markers related to cardiovascular disease: the ATTICA study. Zampelas, A., Panagiotakos, D.B., Pitsavos, C., Das, U.N., Chrysohoou, C., Skoumas, Y., Stefanadis, C. J. Am. Coll. Cardiol. (2005) [Pubmed]
  9. Plasma glucose within the normal range is not associated with carotid atherosclerosis: prospective results in subjects with normal glucose tolerance from the Bruneck Study. Bonora, E., Kiechl, S., Willeit, J., Oberhollenzer, F., Egger, G., Bonadonna, R., Muggeo, M. Diabetes Care (1999) [Pubmed]
  10. Presence of prion protein in peripheral tissues of Libyan Jews with Creutzfeldt-Jakob disease. Meiner, Z., Halimi, M., Polakiewicz, R.D., Prusiner, S.B., Gabizon, R. Neurology (1992) [Pubmed]
  11. Regulation of immune responses through inhibitory receptors. Long, E.O. Annu. Rev. Immunol. (1999) [Pubmed]
  12. Regulation of immune responses by TGF-beta. Letterio, J.J., Roberts, A.B. Annu. Rev. Immunol. (1998) [Pubmed]
  13. CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. Tedder, T.F., Tuscano, J., Sato, S., Kehrl, J.H. Annu. Rev. Immunol. (1997) [Pubmed]
  14. The molecular biology of leukocyte chemoattractant receptors. Murphy, P.M. Annu. Rev. Immunol. (1994) [Pubmed]
  15. CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Trowbridge, I.S., Thomas, M.L. Annu. Rev. Immunol. (1994) [Pubmed]
  16. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Weitz-Schmidt, G., Welzenbach, K., Brinkmann, V., Kamata, T., Kallen, J., Bruns, C., Cottens, S., Takada, Y., Hommel, U. Nat. Med. (2001) [Pubmed]
  17. High efficiency latency and activation of herpes simplex virus in human cells. Wigdahl, B.L., Scheck, A.C., De Clercq, E., Rapp, F. Science (1982) [Pubmed]
  18. Dipstick urinalysis screening of asymptomatic adults for urinary tract disorders. II. Bacteriuria. Pels, R.J., Bor, D.H., Woolhandler, S., Himmelstein, D.U., Lawrence, R.S. JAMA (1989) [Pubmed]
  19. Vidarabine monophosphate and human leukocyte interferon in chronic hepatitis B infection. Smith, C.I., Kitchen, L.W., Scullard, G.H., Robinson, W.S., Gregory, P.B., Merigan, T.C. JAMA (1982) [Pubmed]
  20. Unsuspected osteomyelitis in diabetic foot ulcers. Diagnosis and monitoring by leukocyte scanning with indium in 111 oxyquinoline. Newman, L.G., Waller, J., Palestro, C.J., Schwartz, M., Klein, M.J., Hermann, G., Harrington, E., Harrington, M., Roman, S.H., Stagnaro-Green, A. JAMA (1991) [Pubmed]
  21. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Hoffman, H.M., Mueller, J.L., Broide, D.H., Wanderer, A.A., Kolodner, R.D. Nat. Genet. (2001) [Pubmed]
  22. The effect of somatostatin on coagulation and platelet function in man. Mielke, C.H., Gerich, J.E., Lorenzi, M., Tsalikian, E., Rodvien, R., Forsham, P.H. N. Engl. J. Med. (1975) [Pubmed]
  23. The IIb-IIIa glycoprotein complex that mediates platelet aggregation is directly implicated in leukocyte adhesion. Burns, G.F., Cosgrove, L., Triglia, T., Beall, J.A., López, A.F., Werkmeister, J.A., Begley, C.G., Haddad, A.P., d'Apice, A.J., Vadas, M.A. Cell (1986) [Pubmed]
  24. Germline mutations of the p53 tumor-suppressor gene in children and young adults with second malignant neoplasms. Malkin, D., Jolly, K.W., Barbier, N., Look, A.T., Friend, S.H., Gebhardt, M.C., Andersen, T.I., Børresen, A.L., Li, F.P., Garber, J. N. Engl. J. Med. (1992) [Pubmed]
  25. Susceptibility to infection and altered hematopoiesis in mice deficient in both P- and E-selectins. Frenette, P.S., Mayadas, T.N., Rayburn, H., Hynes, R.O., Wagner, D.D. Cell (1996) [Pubmed]
  26. The use of lithium carbonate to reduce infection and leukopenia during systemic chemotherapy. Lyman, G.H., Williams, C.C., Preston, D. N. Engl. J. Med. (1980) [Pubmed]
  27. Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes. Osborn, L., Hession, C., Tizard, R., Vassallo, C., Luhowskyj, S., Chi-Rosso, G., Lobb, R. Cell (1989) [Pubmed]
  28. Deficiency of enzymes catalyzing the biosynthesis of glycerol-ether lipids in Zellweger syndrome. A new category of metabolic disease involving the absence of peroxisomes. Datta, N.S., Wilson, G.N., Hajra, A.K. N. Engl. J. Med. (1984) [Pubmed]
  29. Leukocyte activation in allergen-induced late-phase asthmatic reactions. Durham, S.R., Carroll, M., Walsh, G.M., Kay, A.B. N. Engl. J. Med. (1984) [Pubmed]
  30. VLA proteins in the integrin family: structures, functions, and their role on leukocytes. Hemler, M.E. Annu. Rev. Immunol. (1990) [Pubmed]
  31. Chemoattractant receptors on phagocytic cells. Snyderman, R., Pike, M.C. Annu. Rev. Immunol. (1984) [Pubmed]
  32. Leukocyte protein tyrosine kinases: potential targets for drug discovery. Bolen, J.B., Brugge, J.S. Annu. Rev. Immunol. (1997) [Pubmed]
  33. Mechanisms that regulate the function of the selectins and their ligands. Vestweber, D., Blanks, J.E. Physiol. Rev. (1999) [Pubmed]
  34. Letter: Reagin-mediated histamine release from human leukocytes by human IgG. Vijay, H.M., Perelmutter, L. N. Engl. J. Med. (1975) [Pubmed]
  35. Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Imai, T., Hieshima, K., Haskell, C., Baba, M., Nagira, M., Nishimura, M., Kakizaki, M., Takagi, S., Nomiyama, H., Schall, T.J., Yoshie, O. Cell (1997) [Pubmed]
  36. Conversion of proepithelin to epithelins: roles of SLPI and elastase in host defense and wound repair. Zhu, J., Nathan, C., Jin, W., Sim, D., Ashcroft, G.S., Wahl, S.M., Lacomis, L., Erdjument-Bromage, H., Tempst, P., Wright, C.D., Ding, A. Cell (2002) [Pubmed]
  37. Epistatic interaction between KIR3DS1 and HLA-B delays the progression to AIDS. Martin, M.P., Gao, X., Lee, J.H., Nelson, G.W., Detels, R., Goedert, J.J., Buchbinder, S., Hoots, K., Vlahov, D., Trowsdale, J., Wilson, M., O'Brien, S.J., Carrington, M. Nat. Genet. (2002) [Pubmed]
  38. Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes. McDermott, M.F., Aksentijevich, I., Galon, J., McDermott, E.M., Ogunkolade, B.W., Centola, M., Mansfield, E., Gadina, M., Karenko, L., Pettersson, T., McCarthy, J., Frucht, D.M., Aringer, M., Torosyan, Y., Teppo, A.M., Wilson, M., Karaarslan, H.M., Wan, Y., Todd, I., Wood, G., Schlimgen, R., Kumarajeewa, T.R., Cooper, S.M., Vella, J.P., Amos, C.I., Mulley, J., Quane, K.A., Molloy, M.G., Ranki, A., Powell, R.J., Hitman, G.A., O'Shea, J.J., Kastner, D.L. Cell (1999) [Pubmed]
  39. The fibrin-derived peptide Bbeta15-42 protects the myocardium against ischemia-reperfusion injury. Petzelbauer, P., Zacharowski, P.A., Miyazaki, Y., Friedl, P., Wickenhauser, G., Castellino, F.J., Gröger, M., Wolff, K., Zacharowski, K. Nat. Med. (2005) [Pubmed]
  40. Molecular cloning of ICAM-3, a third ligand for LFA-1, constitutively expressed on resting leukocytes. Fawcett, J., Holness, C.L., Needham, L.A., Turley, H., Gatter, K.C., Mason, D.Y., Simmons, D.L. Nature (1992) [Pubmed]
  41. Apoptosis disables CD31-mediated cell detachment from phagocytes promoting binding and engulfment. Brown, S., Heinisch, I., Ross, E., Shaw, K., Buckley, C.D., Savill, J. Nature (2002) [Pubmed]
  42. Interferon-neutralizing antibodies in a patient treated with human fibroblast interferon. Vallbracht, A., Treuner, J., Flehmig, B., Joester, K.E., Niethammer, D. Nature (1981) [Pubmed]
  43. Successful long-term immunotherapy for human seminal plasma anaphylaxis. Friedman, S.A., Bernstein, I.L., Enrione, M., Marcus, Z.H. JAMA (1984) [Pubmed]
 
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