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Gene Review

EIF4G1  -  eukaryotic translation initiation factor 4...

Sus scrofa

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Disease relevance of EIF4GI

  • The SVDV 2A protease cleaves the 1D-2A junction in the viral polyprotein, induces cleavage of translation initiation factor eIF4GI, and stimulates the activity of enterovirus internal ribosome entry sites (IRESs) [1].


  1. Importance of arginine 20 of the swine vesicular disease virus 2A protease for activity and virulence. Inoue, T., Alexandersen, S., Clark, A.T., Murphy, C., Quan, M., Reid, S.M., Sakoda, Y., Johns, H.L., Belsham, G.J. J. Virol. (2005) [Pubmed]
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