Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

na - narrow abdomen

Drosophila melanogaster

Synonyms: CG1517, Dma1U, Dmalpha1U, Dmel\CG1517, NA, ...

Nishikawa, K. et al., Mir, B. et al., Lear, B.C. et al.

Nishikawa, Kidokoro,

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High impact information on na

Drosophila mutants of a putative ion channel, narrow abdomen (na), exhibit poor circadian rhythms and suppressed daylight activity [1].
We describe a genetic and behavioral analysis of several alleles of har38, a mutant with altered sensitivity to the general anesthetic halothane [2].
Halothane presynaptically depresses synaptic transmission in wild-type Drosophila larvae but not in halothane-resistant (har) mutants [3].
METHODS: The authors evaluated the effect of halothane on synaptic transmission at the larval neuromuscular junction in wild-type (Ore-R) and halothane-resistant (har) mutants of Drosophila melanogaster [3].
The absence of an effect by halothane in the har mutants provides evidence that the depression of presynaptic function at the glutamate-mediated synapses is an important contributor to the way halothane alters the responsiveness of the whole animal [3].

References

The ion channel narrow abdomen is critical for neural output of the Drosophila circadian pacemaker. Lear, B.C., Lin, J.M., Keath, J.R., McGill, J.J., Raman, I.M., Allada, R. Neuron (2005) [Pubmed]
A genetic and mosaic analysis of a locus involved in the anesthesia response of Drosophila melanogaster. Mir, B., Iyer, S., Ramaswami, M., Krishnan, K.S. Genetics (1997) [Pubmed]
Halothane presynaptically depresses synaptic transmission in wild-type Drosophila larvae but not in halothane-resistant (har) mutants. Nishikawa, K., Kidokoro, Y. Anesthesiology (1999) [Pubmed]

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AgaP_AGAP003921	Anopheles gambiae str. PEST
NALCN	Bos taurus
unc-77	Caenorhabditis elegans
nca-2	Caenorhabditis elegans
NALCN	Canis lupus familiaris
nalcn	Danio rerio
NALCN	Gallus gallus
NALCN	Homo sapiens
Nalcn	Mus musculus
NALCN	Pan troglodytes
Nalcn	Rattus norvegicus
nalcn	Xenopus (Silurana) tropicalis

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