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Gene Review:

Pep - Protein on ecdysone puffs

Drosophila melanogaster

Synonyms: CG6143, Dmel\CG6143, PEP, PEP/X4, X4/PEP, ...

Belikov, S.V. et al., Amero, S.A. et al.

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High impact information on Pep

Two non-histone proteins with apparent molecular masses of 50 kD (p50) and 100 kD (p100) are crosslinked only to the active hsp-70 gene regulatory region and preferentially bind to its complementary and coding DNA strands, respectively [1].

Analytical, diagnostic and therapeutic context of Pep

The Pep gene maps by in situ hybridization to the cytological locus 74F, adjacent to the early ecdysone-responsive region; however, the gene is not regulated by ecdysone at the level of transcription [2].

References

Two non-histone proteins are associated with the promoter region and histone HI with the transcribed region of active hsp-70 genes as revealed by UV-induced DNA-protein crosslinking in vivo. Belikov, S.V., Belgovsky, A.I., Preobrazhenskaya, O.V., Karpov, V.L., Mirzabekov, A.D. Nucleic Acids Res. (1993) [Pubmed]
A unique zinc finger protein is associated preferentially with active ecdysone-responsive loci in Drosophila. Amero, S.A., Elgin, S.C., Beyer, A.L. Genes Dev. (1991) [Pubmed]

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