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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MYBPC1  -  myosin binding protein C, slow type

Homo sapiens

Synonyms: C-protein, skeletal muscle slow isoform, LCCS4, MYBPCC, MYBPCS, Myosin-binding protein C, slow-type, ...
 
 
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High impact information on MYBPC1

  • Immunological evidence also suggests that an embryonic isoform of MyBP-C precedes the expression of slow MyBP-C in developing skeletal muscle [1].
  • This MyBP-C isoform had a migration rate similar to the slow MyBP-C isoform in limb muscle fibers [2].
  • Compared to the benign phenotypes the expression of MYBPC-1 was particularly increased in SCC cells, confirmed by Northern hybridization [3].

References

  1. Isoform transitions of the myosin binding protein C family in developing human and mouse muscles: lack of isoform transcomplementation in cardiac muscle. Gautel, M., Fürst, D.O., Cocco, A., Schiaffino, S. Circ. Res. (1998) [Pubmed]
  2. Human single masseter muscle fibers contain unique combinations of myosin and myosin binding protein C isoforms. Yu, F., Stål, P., Thornell, L.E., Larsson, L. J. Muscle Res. Cell. Motil. (2002) [Pubmed]
  3. Overexpression of the human myosin-binding protein-C1 mRNA in laryngeal squamous cell carcinoma cells. Beier, U.H., Görögh, T., Holtmeier, C., Ambrosch, P., Maune, S. Anticancer Res. (2002) [Pubmed]
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