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Gene Review

NFX1  -  nuclear transcription factor, X-box binding 1

Homo sapiens

Synonyms: MGC20369, NFX2, Nuclear transcription factor, X box-binding protein 1, TEG-42, Tex42, ...
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High impact information on NFX1

  • Here, we show that HPV16 E6 bound both NFX1-91 and NFX1-123 through the common central domain of NFX1 in the absence of E6AP [1].
  • In contrast, NFX1-123, a splice variant NFX1, increased expression from an hTERT promoter that was activated by HPV16 E6/E6AP [1].
  • The resulting butyrolactone products are transformed into natural trisubstituted butyrolactones including (+)-blastmycinone, (+)-blastmycinolactol, (+)-antimycinone, NFX-2, and (+)-isodihydromahubanolide A [2].


  1. NFX1-123 and Poly(A) Binding Proteins Synergistically Augment Activation of Telomerase in Human Papillomavirus Type 16 E6-Expressing Cells. Katzenellenbogen, R.A., Egelkrout, E.M., Vliet-Gregg, P., Gewin, L.C., Gafken, P.R., Galloway, D.A. J. Virol. (2007) [Pubmed]
  2. Total synthesis of (+)-blastmycinone, (-)-litsenolide C1, and related natural trisubstituted lactones via alkynyltungsten compounds. Chen, M.J., Lo, C.Y., Chin, C.C., Liu, R.S. J. Org. Chem. (2000) [Pubmed]
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