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Gene Review:

Grip - Glutamate receptor binding protein

Drosophila melanogaster

Synonyms: CG14447, CG5980, DGrip, Dgrip, Dmel\CG14447, ...

Swan, L.E. et al., Swan, L.E. et al.

Swan, Schmidt, Schwarz, Ponimaskin, Prange, Boeckers, Thomas, Sigrist,

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High impact information on Grip

This dgrip phenotype should be valuable to study mechanistic principles of Grip function [1].
Here, we show that the homolog of Glutamate Receptor-Interacting Proteins (DGrip) acts as a key component of proper muscle guidance [1].
Myoblast fusion, stabilization of muscle contacts, and general muscle function are not impaired in the absence of DGrip [1].
Yeast two-hybrid screening identifies the cell adhesion protein Echinoid's (Ed) type II PDZD-interaction motif as binding PDZDs 1, 2 and 7 of DGrip. ed loss-of-function alleles exhibit muscle defects, enhance defects caused by reduced DGrip activity and suppress the dominant DGripDelta1-3 effect during embryonic muscle formation [2].

References

A glutamate receptor-interacting protein homolog organizes muscle guidance in Drosophila. Swan, L.E., Wichmann, C., Prange, U., Schmid, A., Schmidt, M., Schwarz, T., Ponimaskin, E., Madeo, F., Vorbrüggen, G., Sigrist, S.J. Genes Dev. (2004) [Pubmed]
Complex interaction of Drosophila GRIP PDZ domains and Echinoid during muscle morphogenesis. Swan, L.E., Schmidt, M., Schwarz, T., Ponimaskin, E., Prange, U., Boeckers, T., Thomas, U., Sigrist, S.J. EMBO J. (2006) [Pubmed]

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