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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Adhesion

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Disease relevance of Cell Adhesion


Psychiatry related information on Cell Adhesion


High impact information on Cell Adhesion


Chemical compound and disease context of Cell Adhesion


Biological context of Cell Adhesion


Anatomical context of Cell Adhesion


Associations of Cell Adhesion with chemical compounds

  • We show here that multiple members of the integrin superfamily of cell adhesion receptors bind the Y. pseudotuberculosis invasin protein prior to bacterial penetration into mammalian cells [31].
  • These properties suggest that the 140 kd glycoprotein is a membrane-embedded cell surface protein directly involved in the initial step of cell adhesion to fibronectin substrates [32].
  • Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations [33].
  • The module contains an Arg-Gly-Asp sequence known to be involved in cell adhesion [34].
  • We propose that specific alpha(1,3)fucosyltransferases regulate cell adhesion to ELAM-1 by modulating cell surface expression of one or more alpha(2,3)sialylated, alpha(1,3)fucosylated lactosaminoglycans represented by the sialyl Lewis x carbohydrate determinant [28].

Gene context of Cell Adhesion


Analytical, diagnostic and therapeutic context of Cell Adhesion


  1. The carbonic anhydrase domain of receptor tyrosine phosphatase beta is a functional ligand for the axonal cell recognition molecule contactin. Peles, E., Nativ, M., Campbell, P.L., Sakurai, T., Martinez, R., Lev, S., Clary, D.O., Schilling, J., Barnea, G., Plowman, G.D., Grumet, M., Schlessinger, J. Cell (1995) [Pubmed]
  2. Cadherin expression is required for the spread of Shigella flexneri between epithelial cells. Sansonetti, P.J., Mounier, J., Prévost, M.C., Mège, R.M. Cell (1994) [Pubmed]
  3. Autoantibodies against a novel epithelial cadherin in pemphigus vulgaris, a disease of cell adhesion. Amagai, M., Klaus-Kovtun, V., Stanley, J.R. Cell (1991) [Pubmed]
  4. A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses. Staunton, D.E., Merluzzi, V.J., Rothlein, R., Barton, R., Marlin, S.D., Springer, T.A. Cell (1989) [Pubmed]
  5. A polymeric form of fibronectin has antimetastatic effects against multiple tumor types. Pasqualini, R., Bourdoulous, S., Koivunen, E., Woods, V.L., Ruoslahti, E. Nat. Med. (1996) [Pubmed]
  6. A 109-amino-acid C-terminal fragment of Alzheimer's-disease amyloid precursor protein contains a sequence, -RHDS-, that promotes cell adhesion. Ghiso, J., Rostagno, A., Gardella, J.E., Liem, L., Gorevic, P.D., Frangione, B. Biochem. J. (1992) [Pubmed]
  7. A surface glycoprotein complex related to the adhesive receptors of the VLA family, shared by epidermal Langerhans cells and basal keratinocytes. Staquet, M.J., Dezutter-Dambuyant, C., Schmitt, D., Amiot, M., Boumsell, L., Thivolet, J. J. Invest. Dermatol. (1989) [Pubmed]
  8. Effects of acute psychological stress on adhesion molecules, interleukins and sex hormones: implications for coronary heart disease. Heinz, A., Hermann, D., Smolka, M.N., Rieks, M., Gräf, K.J., Pöhlau, D., Kuhn, W., Bauer, M. Psychopharmacology (Berl.) (2003) [Pubmed]
  9. Adhesion of corneal epithelial cells to cell adhesion peptide modified pHEMA surfaces. Merrett, K., Griffith, C.M., Deslandes, Y., Pleizier, G., Sheardown, H. Journal of biomaterials science. Polymer edition. (2001) [Pubmed]
  10. Assessment of novel risk factors in patients at low risk for cardiovascular events based on Framingham risk stratification. Grewal, J., Chan, S., Frohlich, J., Mancini, G.B. Clinical and investigative medicine. Médecine clinique et experimentale. (2003) [Pubmed]
  11. The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system. Springer, T.A., Dustin, M.L., Kishimoto, T.K., Marlin, S.D. Annu. Rev. Immunol. (1987) [Pubmed]
  12. The molecular structure of cell adhesion molecules. Chothia, C., Jones, E.Y. Annu. Rev. Biochem. (1997) [Pubmed]
  13. Mechanisms that regulate the function of the selectins and their ligands. Vestweber, D., Blanks, J.E. Physiol. Rev. (1999) [Pubmed]
  14. Cellular actions of beta-amyloid precursor protein and its soluble and fibrillogenic derivatives. Mattson, M.P. Physiol. Rev. (1997) [Pubmed]
  15. A mitochondrial protein, Bit1, mediates apoptosis regulated by integrins and Groucho/TLE corepressors. Jan, Y., Matter, M., Pai, J.T., Chen, Y.L., Pilch, J., Komatsu, M., Ong, E., Fukuda, M., Ruoslahti, E. Cell (2004) [Pubmed]
  16. Identification of a CD36-related thrombospondin 1-binding domain in HIV-1 envelope glycoprotein gp120: relationship to HIV-1-specific inhibitory factors in human saliva. Crombie, R., Silverstein, R.L., MacLow, C., Pearce, S.F., Nachman, R.L., Laurence, J. J. Exp. Med. (1998) [Pubmed]
  17. The integrin VLA-2 binds echovirus 1 and extracellular matrix ligands by different mechanisms. Bergelson, J.M., Chan, B.M., Finberg, R.W., Hemler, M.E. J. Clin. Invest. (1993) [Pubmed]
  18. Metastasis inhibition of different tumor types by purified laminin fragments and a heparin-binding fragment of fibronectin. McCarthy, J.B., Skubitz, A.P., Palm, S.L., Furcht, L.T. J. Natl. Cancer Inst. (1988) [Pubmed]
  19. Isolation of a novel integrin receptor mediating Arg-Gly-Asp-directed cell adhesion to fibronectin and type I collagen from human neuroblastoma cells. Association of a novel beta 1-related subunit with alpha v. Dedhar, S., Gray, V. J. Cell Biol. (1990) [Pubmed]
  20. Cell surface phosphatidylinositol-anchored heparan sulfate proteoglycan initiates mouse melanoma cell adhesion to a fibronectin-derived, heparin-binding synthetic peptide. Drake, S.L., Klein, D.J., Mickelson, D.J., Oegema, T.R., Furcht, L.T., McCarthy, J.B. J. Cell Biol. (1992) [Pubmed]
  21. PIK3CA is implicated as an oncogene in ovarian cancer. Shayesteh, L., Lu, Y., Kuo, W.L., Baldocchi, R., Godfrey, T., Collins, C., Pinkel, D., Powell, B., Mills, G.B., Gray, J.W. Nat. Genet. (1999) [Pubmed]
  22. The Drosophila beaten path gene encodes a novel secreted protein that regulates defasciculation at motor axon choice points. Fambrough, D., Goodman, C.S. Cell (1996) [Pubmed]
  23. OPCML at 11q25 is epigenetically inactivated and has tumor-suppressor function in epithelial ovarian cancer. Sellar, G.C., Watt, K.P., Rabiasz, G.J., Stronach, E.A., Li, L., Miller, E.P., Massie, C.E., Miller, J., Contreras-Moreira, B., Scott, D., Brown, I., Williams, A.R., Bates, P.A., Smyth, J.F., Gabra, H. Nat. Genet. (2003) [Pubmed]
  24. Prevention of gastrulation but not neurulation by antibodies to fibronectin in amphibian embryos. Boucaut, J.C., Darribère, T., Boulekbache, H., Thiery, J.P. Nature (1984) [Pubmed]
  25. Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation. Guan, J.L., Shalloway, D. Nature (1992) [Pubmed]
  26. Epiligrin, a new cell adhesion ligand for integrin alpha 3 beta 1 in epithelial basement membranes. Carter, W.G., Ryan, M.C., Gahr, P.J. Cell (1991) [Pubmed]
  27. Desmoglein 4 in hair follicle differentiation and epidermal adhesion: evidence from inherited hypotrichosis and acquired pemphigus vulgaris. Kljuic, A., Bazzi, H., Sundberg, J.P., Martinez-Mir, A., O'Shaughnessy, R., Mahoney, M.G., Levy, M., Montagutelli, X., Ahmad, W., Aita, V.M., Gordon, D., Uitto, J., Whiting, D., Ott, J., Fischer, S., Gilliam, T.C., Jahoda, C.A., Morris, R.J., Panteleyev, A.A., Nguyen, V.T., Christiano, A.M. Cell (2003) [Pubmed]
  28. ELAM-1--dependent cell adhesion to vascular endothelium determined by a transfected human fucosyltransferase cDNA. Lowe, J.B., Stoolman, L.M., Nair, R.P., Larsen, R.D., Berhend, T.L., Marks, R.M. Cell (1990) [Pubmed]
  29. Functional SNPs in the lymphotoxin-alpha gene that are associated with susceptibility to myocardial infarction. Ozaki, K., Ohnishi, Y., Iida, A., Sekine, A., Yamada, R., Tsunoda, T., Sato, H., Sato, H., Hori, M., Nakamura, Y., Tanaka, T. Nat. Genet. (2002) [Pubmed]
  30. Leukocyte accumulation promoting fibrin deposition is mediated in vivo by P-selectin on adherent platelets. Palabrica, T., Lobb, R., Furie, B.C., Aronovitz, M., Benjamin, C., Hsu, Y.M., Sajer, S.A., Furie, B. Nature (1992) [Pubmed]
  31. Multiple beta 1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells. Isberg, R.R., Leong, J.M. Cell (1990) [Pubmed]
  32. Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor. Pytela, R., Pierschbacher, M.D., Ruoslahti, E. Cell (1985) [Pubmed]
  33. Genetic analysis of a Drosophila neural cell adhesion molecule: interaction of fasciclin I and Abelson tyrosine kinase mutations. Elkins, T., Zinn, K., McAllister, L., Hoffmann, F.M., Goodman, C.S. Cell (1990) [Pubmed]
  34. The three-dimensional structure of the tenth type III module of fibronectin: an insight into RGD-mediated interactions. Main, A.L., Harvey, T.S., Baron, M., Boyd, J., Campbell, I.D. Cell (1992) [Pubmed]
  35. The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression. Nagafuchi, A., Takeichi, M., Tsukita, S. Cell (1991) [Pubmed]
  36. Three-dimensional structure of the armadillo repeat region of beta-catenin. Huber, A.H., Nelson, W.J., Weis, W.I. Cell (1997) [Pubmed]
  37. MASA syndrome is due to mutations in the neural cell adhesion gene L1CAM. Vits, L., Van Camp, G., Coucke, P., Fransen, E., De Boulle, K., Reyniers, E., Korn, B., Poustka, A., Wilson, G., Schrander-Stumpel, C. Nat. Genet. (1994) [Pubmed]
  38. Secrets of a secretase: N-cadherin proteolysis regulates CBP function. Rao, V.R., Finkbeiner, S. Cell (2003) [Pubmed]
  39. Functional cloning of ICAM-2, a cell adhesion ligand for LFA-1 homologous to ICAM-1. Staunton, D.E., Dustin, M.L., Springer, T.A. Nature (1989) [Pubmed]
  40. Fasciclin III: a novel homophilic adhesion molecule in Drosophila. Snow, P.M., Bieber, A.J., Goodman, C.S. Cell (1989) [Pubmed]
  41. Temporally specific involvement of cell surface beta-1,4 galactosyltransferase during mouse embryo morula compaction. Bayna, E.M., Shaper, J.H., Shur, B.D. Cell (1988) [Pubmed]
  42. Crystal structure of hemolin: a horseshoe shape with implications for homophilic adhesion. Su, X.D., Gastinel, L.N., Vaughn, D.E., Faye, I., Poon, P., Bjorkman, P.J. Science (1998) [Pubmed]
  43. P-selectin glycoprotein ligand-1 (PSGL-1) on T helper 1 but not on T helper 2 cells binds to P-selectin and supports migration into inflamed skin. Borges, E., Tietz, W., Steegmaier, M., Moll, T., Hallmann, R., Hamann, A., Vestweber, D. J. Exp. Med. (1997) [Pubmed]
  44. Molecular cloning and functional expression of gicerin, a novel cell adhesion molecule that binds to neurite outgrowth factor. Taira, E., Takaha, N., Taniura, H., Kim, C.H., Miki, N. Neuron (1994) [Pubmed]
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