The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

APH1A  -  APH1A gamma secretase subunit

Homo sapiens

Synonyms: 6530402N02Rik, APH-1, APH-1A, APH-1a, Aph-1alpha, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on APH1A

  • Only the combined overexpression of PS1 and NCT together with APH-1a G122D facilitated the formation of a fully active gamma-secretase complex [1].
  • We conclude that cooperative effects may stabilize a trim-eric complex of APH-1a G122D together with PS1 and NCT [1].
  • Under these conditions, APH-1a G122D supported the production of normal amounts of Abeta [1].
  • Here we show that both APH-1a splice forms and APH-1b are expressed in peripheral and neuronal cells [2].
  • Using the APH-1 protein encoded on human chromosome 1 (APH-1(1)L; also known as APH-1a) as an archetype, we report here that endogenous forms of APH-1 are predominantly expressed in intracellular membrane compartments, including the endoplasmic reticulum and cis-Golgi [3].

Biological context of APH1A


  1. Co-expression of nicastrin and presenilin rescues a loss of function mutant of APH-1. Edbauer, D., Kaether, C., Steiner, H., Haass, C. J. Biol. Chem. (2004) [Pubmed]
  2. Identification of distinct gamma-secretase complexes with different APH-1 variants. Shirotani, K., Edbauer, D., Prokop, S., Haass, C., Steiner, H. J. Biol. Chem. (2004) [Pubmed]
  3. APH-1 interacts with mature and immature forms of presenilins and nicastrin and may play a role in maturation of presenilin.nicastrin complexes. Gu, Y., Chen, F., Sanjo, N., Kawarai, T., Hasegawa, H., Duthie, M., Li, W., Ruan, X., Luthra, A., Mount, H.T., Tandon, A., Fraser, P.E., St George-Hyslop, P. J. Biol. Chem. (2003) [Pubmed]
  4. Expression profiles of two human APH-1 genes and their roles in formation of presenilin complexes. Saito, S., Araki, W. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  5. Transcriptional regulation of APH-1A and increased gamma-secretase cleavage of APP and Notch by HIF-1 and hypoxia. Wang, R., Zhang, Y.W., Zhang, X., Liu, R., Zhang, X., Hong, S., Xia, K., Xia, J., Zhang, Z., Xu, H. FASEB J. (2006) [Pubmed]
WikiGenes - Universities