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Gene Review:

SHISA5 - shisa family member 5

Homo sapiens

Synonyms: PSEC0133, Protein shisa-5, SCOTIN, Scotin, hShisa5

Terrinoni, A. et al., Rossi, M. et al.

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High impact information on SCOTIN

We found that both TAp73alpha and p53 are strong inducers of scotin [1].
In conclusion, the data reported indicate the ability of TAp73alpha and p53 (not DeltaNp73alpha) to elicit scotin transactivation and ER stress [1].
Following the induction of scotin, ER staining with calnexin showed evidence of morphological alteration, with variations in the intracellular concentration of free calcium, visualized by fluo-3 staining [1].
The molecular mechanism through which p73 induces apoptosis involves (i) expression and changes in subcellular localization of scotin, producing an endoplasmic reticulum (ER) stress; and (ii) transactivation of PUMA and Bax, thus determining cell fate [2].

Anatomical context of SCOTIN

Here, we report that this mechanism also involves endoplasmic reticulum (ER) stress and the transactivation of scotin, a protein identified recently as a p53 target able to induce ER stress [1].

Analytical, diagnostic and therapeutic context of SCOTIN

On the other hand, the transcriptionally deficient short isoforms DeltaNp73alpha did not upregulate the steady-state mRNA level of scotin, as evaluated by real-time RT-PCR [1].

References

p73-alpha is capable of inducing scotin and ER stress. Terrinoni, A., Ranalli, M., Cadot, B., Leta, A., Bagetta, G., Vousden, K.H., Melino, G. Oncogene (2004) [Pubmed]
Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology. Rossi, M., Sayan, A.E., Terrinoni, A., Melino, G., Knight, R.A. Ann. N. Y. Acad. Sci. (2004) [Pubmed]

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SHISA5	Bos taurus
LOC709615	Macaca mulatta
Shisa5	Mus musculus
SHISA5	Pan troglodytes
Shisa5	Rattus norvegicus

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