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Gene Review

SHISA5  -  shisa family member 5

Homo sapiens

Synonyms: PSEC0133, Protein shisa-5, SCOTIN, Scotin, hShisa5
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High impact information on SCOTIN

  • We found that both TAp73alpha and p53 are strong inducers of scotin [1].
  • In conclusion, the data reported indicate the ability of TAp73alpha and p53 (not DeltaNp73alpha) to elicit scotin transactivation and ER stress [1].
  • Following the induction of scotin, ER staining with calnexin showed evidence of morphological alteration, with variations in the intracellular concentration of free calcium, visualized by fluo-3 staining [1].
  • The molecular mechanism through which p73 induces apoptosis involves (i) expression and changes in subcellular localization of scotin, producing an endoplasmic reticulum (ER) stress; and (ii) transactivation of PUMA and Bax, thus determining cell fate [2].

Anatomical context of SCOTIN


Analytical, diagnostic and therapeutic context of SCOTIN

  • On the other hand, the transcriptionally deficient short isoforms DeltaNp73alpha did not upregulate the steady-state mRNA level of scotin, as evaluated by real-time RT-PCR [1].


  1. p73-alpha is capable of inducing scotin and ER stress. Terrinoni, A., Ranalli, M., Cadot, B., Leta, A., Bagetta, G., Vousden, K.H., Melino, G. Oncogene (2004) [Pubmed]
  2. Mechanism of induction of apoptosis by p73 and its relevance to neuroblastoma biology. Rossi, M., Sayan, A.E., Terrinoni, A., Melino, G., Knight, R.A. Ann. N. Y. Acad. Sci. (2004) [Pubmed]
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