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ITIH4  -  inter-alpha-trypsin inhibitor heavy chain...

Bos taurus

 
 
 
 
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Disease relevance of ITIH4

  • All animals developed moderate to severe clinical mastitis and exhibited remarkable increases in ITIH4 concentration in serum (from 3 to 12 times the initial values, peaking at 48 to 72 h after infection) that correlated with the severity of the disease [1].
  • Animals with experimental infections with bovine respiratory syncytial virus (BRSV) also showed increases in ITIH4 concentration (from two- to fivefold), which peaked at around 7 to 8 days after inoculation [1].
 

High impact information on ITIH4

  • The amino acid sequence of an internal fragment revealed that this protein is the bovine counterpart of ITIH4, the heavy chain 4 of the inter-alpha-trypsin inhibitor family [1].

References

  1. ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4) is a new acute-phase protein isolated from cattle during experimental infection. Piñeiro, M., Andrés, M., Iturralde, M., Carmona, S., Hirvonen, J., Pyörälä, S., Heegaard, P.M., Tjørnehøj, K., Lampreave, F., Piñeiro, A., Alava, M.A. Infect. Immun. (2004) [Pubmed]
 
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