The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PIGC  -  phosphatidylinositol glycan anchor...

Homo sapiens

Synonyms: GPI2, PIG-C, Phosphatidylinositol N-acetylglucosaminyltransferase subunit C, Phosphatidylinositol-glycan biosynthesis class C protein
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on PIGC

  • GPI-GnT is a uniquely complex glycosyltransferase, consisting of at least four proteins, PIG-A, PIG-H, PIG-C and GPI1 [1].
  • Therefore, GPI1 stabilizes the enzyme by tying up PIG-C with a complex of PIG-A and PIG-H [2].
  • Moreover, we show preliminary evidence for the PIG-L and PIG-C genes [3].
  • Linkage group 5 contains GPI-2 and PEP-D (peptidase D) [4].
  • Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1 [5].

Biological context of PIGC

  • Here we isolated a genomic clone of another GPI-synthesis gene, PIGC, and mapped it to chromosome 1q23-q25, further supporting this notion [5].
  • Frequencies of shiners with a GPI-2 BB genotype decreased significantly at sites with reduced water quality [6].

Anatomical context of PIGC


Other interactions of PIGC

  • A lack of GPI1 also caused partial decreases of PIG-C and PIG-H [2].


  1. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. Watanabe, R., Murakami, Y., Marmor, M.D., Inoue, N., Maeda, Y., Hino, J., Kangawa, K., Julius, M., Kinoshita, T. EMBO J. (2000) [Pubmed]
  2. GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis. Hong, Y., Ohishi, K., Watanabe, R., Endo, Y., Maeda, Y., Kinoshita, T. J. Biol. Chem. (1999) [Pubmed]
  3. Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparum. Delorenzi, M., Sexton, A., Shams-Eldin, H., Schwarz, R.T., Speed, T., Schofield, L. Infect. Immun. (2002) [Pubmed]
  4. Genetic mapping in Xenopus laevis: eight linkage groups established. Graf, J.D. Genetics (1989) [Pubmed]
  5. Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1. Hong, Y., Ohishi, K., Inoue, N., Endo, Y., Fujita, T., Takeda, J., Kinoshita, T. Genomics (1997) [Pubmed]
  6. Correlations between water quality and frequencies of allozyme genotypes in spotfin shiner (Notropis spilopteris) populations. Gillespie, R.B., Guttman, S.I. Environ. Pollut. (1993) [Pubmed]
  7. PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2. Inoue, N., Watanabe, R., Takeda, J., Kinoshita, T. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
WikiGenes - Universities