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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

PIGC  -  phosphatidylinositol glycan anchor...

Homo sapiens

Synonyms: GPI2, PIG-C, Phosphatidylinositol N-acetylglucosaminyltransferase subunit C, Phosphatidylinositol-glycan biosynthesis class C protein
 
 
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High impact information on PIGC

  • GPI-GnT is a uniquely complex glycosyltransferase, consisting of at least four proteins, PIG-A, PIG-H, PIG-C and GPI1 [1].
  • Therefore, GPI1 stabilizes the enzyme by tying up PIG-C with a complex of PIG-A and PIG-H [2].
  • Moreover, we show preliminary evidence for the PIG-L and PIG-C genes [3].
  • Linkage group 5 contains GPI-2 and PEP-D (peptidase D) [4].
  • Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1 [5].
 

Biological context of PIGC

  • Here we isolated a genomic clone of another GPI-synthesis gene, PIGC, and mapped it to chromosome 1q23-q25, further supporting this notion [5].
  • Frequencies of shiners with a GPI-2 BB genotype decreased significantly at sites with reduced water quality [6].
 

Anatomical context of PIGC

 

Other interactions of PIGC

  • A lack of GPI1 also caused partial decreases of PIG-C and PIG-H [2].

References

  1. Initial enzyme for glycosylphosphatidylinositol biosynthesis requires PIG-P and is regulated by DPM2. Watanabe, R., Murakami, Y., Marmor, M.D., Inoue, N., Maeda, Y., Hino, J., Kangawa, K., Julius, M., Kinoshita, T. EMBO J. (2000) [Pubmed]
  2. GPI1 stabilizes an enzyme essential in the first step of glycosylphosphatidylinositol biosynthesis. Hong, Y., Ohishi, K., Watanabe, R., Endo, Y., Maeda, Y., Kinoshita, T. J. Biol. Chem. (1999) [Pubmed]
  3. Genes for glycosylphosphatidylinositol toxin biosynthesis in Plasmodium falciparum. Delorenzi, M., Sexton, A., Shams-Eldin, H., Schwarz, R.T., Speed, T., Schofield, L. Infect. Immun. (2002) [Pubmed]
  4. Genetic mapping in Xenopus laevis: eight linkage groups established. Graf, J.D. Genetics (1989) [Pubmed]
  5. Structures and chromosomal localizations of the glycosylphosphatidylinositol synthesis gene PIGC and its pseudogene PIGCP1. Hong, Y., Ohishi, K., Inoue, N., Endo, Y., Fujita, T., Takeda, J., Kinoshita, T. Genomics (1997) [Pubmed]
  6. Correlations between water quality and frequencies of allozyme genotypes in spotfin shiner (Notropis spilopteris) populations. Gillespie, R.B., Guttman, S.I. Environ. Pollut. (1993) [Pubmed]
  7. PIG-C, one of the three human genes involved in the first step of glycosylphosphatidylinositol biosynthesis is a homologue of Saccharomyces cerevisiae GPI2. Inoue, N., Watanabe, R., Takeda, J., Kinoshita, T. Biochem. Biophys. Res. Commun. (1996) [Pubmed]
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