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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CHIC1  -  cysteine-rich hydrophobic domain 1

Homo sapiens

Synonyms: BRX, Brain X-linked protein, Cysteine-rich hydrophobic domain-containing protein 1
 
 
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Disease relevance of CHIC1

 

High impact information on CHIC1

  • The importance of this domain for BRX activity in planta is underscored by our finding that expression of the C-terminal fragment of BRX, comprising the two BRX domains, is largely sufficient to rescue the brx phenotype [2].
  • BRX and BRXL1 similarity is most pronounced in a characteristic tandem repeat domain, which we named BRX domain [2].
  • BRX mediates feedback between brassinosteroid levels and auxin signalling in root growth [3].

References

  1. Localization and expression analysis of a novel conserved brain expressed transcript, Brx/BRX, lying within the Xic/XIC candidate region. Simmler, M.C., Heard, E., Rougeulle, C., Cruaud, C., Weissenbach, J., Avner, P. Mamm. Genome (1997) [Pubmed]
  2. Characterization of the plant-specific BREVIS RADIX gene family reveals limited genetic redundancy despite high sequence conservation. Briggs, G.C., Mouchel, C.F., Hardtke, C.S. Plant Physiol. (2006) [Pubmed]
  3. BRX mediates feedback between brassinosteroid levels and auxin signalling in root growth. Mouchel, C.F., Osmont, K.S., Hardtke, C.S. Nature (2006) [Pubmed]
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