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Gene Review

CHRAC1  -  chromatin accessibility complex 1

Homo sapiens

Synonyms: CHARC1, CHARC15, CHRAC-1, CHRAC-15, CHRAC15, ...
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High impact information on CHRAC1

  • Recent studies have shown that two nucleosome-remodeling complexes, NURF and CHRAC, open chromatin for transcription and replication by using their common catalytic subunit, the nucleosomal ATPase ISWI, to increase the mobility of nucleosomes relative to DNA sequence [1].
  • SWI/SNF, RSC, NURF, CHRAC, ACF, RSF and NuRD are highly conserved multiprotein complexes that use the energy of ATP-hydrolysis to remodel chromatin [2].


  1. SWItched-on mobility. Guschin, D., Wolffe, A.P. Curr. Biol. (1999) [Pubmed]
  2. ATP-dependent chromatin remodelling: SWI/SNF and Co. are on the job. Muchardt, C., Yaniv, M. J. Mol. Biol. (1999) [Pubmed]
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