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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Catalytic Domain

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Disease relevance of Catalytic Domain


Psychiatry related information on Catalytic Domain


High impact information on Catalytic Domain

  • IKK contains two catalytic subunits, IKKalpha and IKKbeta, both of which are able to correctly phosphorylate IkappaB [7].
  • Although lacking catalytic domains, all the receptors couple ligand binding to the rapid induction of protein tyrosine phosphorylation [8].
  • Structure-function analysis of CD45 and other PTPs has identified structural features of PTP catalytic domains required for enzymatic activity [9].
  • Circularly permuted polypeptide chains are being used to study the folding and assembly pathways, and the recently determined crystal structure of the active nonallosteric catalytic subunit has led to new questions regarding the activated form of ATCase [10].
  • Other structural and mutational probes of the F1 and F0 portions of the ATP synthase are reviewed, together with kinetic and other evaluations of catalytic site occupancy and behavior during hydrolysis or synthesis of ATP [11].

Chemical compound and disease context of Catalytic Domain


Biological context of Catalytic Domain


Anatomical context of Catalytic Domain


Associations of Catalytic Domain with chemical compounds

  • Four major serine/threonine-specific protein phosphatase catalytic subunits are present in the cytoplasm of animal cells [22].
  • Protein kinase casein kinase II (Ck2) is a cyclic-AMP and calcium-independent serine-threonine kinase that is composed of two catalytic subunits (alpha and alpha') and two regulatory beta-subunits [27].
  • The posttranslational conversion of cysteine to C(alpha)-formylglycine in the catalytic site of mammalian sulfatases is deficient in the rare but devastating disorder multiple sulfatase deficiency (MSD) [28].
  • A gene (pkn1) thus cloned contains an ORF of 693 amino acid residues whose amino-terminal domain shows significant sequence similarity with the catalytic domain of eukaryotic protein serine/threonine kinases [29].
  • In liver and muscle, loss of the major regulatory isoform caused a great decrease in expression and activity of class IA Pi3k catalytic subunits; nevertheless, homozygous mice still displayed hypoglycaemia, lower insulin levels and increased glucose tolerance [30].

Gene context of Catalytic Domain


Analytical, diagnostic and therapeutic context of Catalytic Domain


  1. The neurospora CYT-18 protein suppresses defects in the phage T4 td intron by stabilizing the catalytically active structure of the intron core. Mohr, G., Zhang, A., Gianelos, J.A., Belfort, M., Lambowitz, A.M. Cell (1992) [Pubmed]
  2. Nonsense mutations in the C-terminal SH2 region of the GTPase activating protein (GAP) gene in human tumours. Friedman, E., Gejman, P.V., Martin, G.A., McCormick, F. Nat. Genet. (1993) [Pubmed]
  3. A novel ubiquitin ligase is deficient in Fanconi anemia. Meetei, A.R., de Winter, J.P., Medhurst, A.L., Wallisch, M., Waisfisz, Q., van de Vrugt, H.J., Oostra, A.B., Yan, Z., Ling, C., Bishop, C.E., Hoatlin, M.E., Joenje, H., Wang, W. Nat. Genet. (2003) [Pubmed]
  4. Colorectal carcinomas in mice lacking the catalytic subunit of PI(3)Kgamma. Sasaki, T., Irie-Sasaki, J., Horie, Y., Bachmaier, K., Fata, J.E., Li, M., Suzuki, A., Bouchard, D., Ho, A., Redston, M., Gallinger, S., Khokha, R., Mak, T.W., Hawkins, P.T., Stephens, L., Scherer, S.W., Tsao, M., Penninger, J.M. Nature (2000) [Pubmed]
  5. Identification of new mutations in two phosphoglycerate kinase (PGK) variants expressing different clinical syndromes: PGK Créteil and PGK Amiens. Cohen-Solal, M., Valentin, C., Plassa, F., Guillemin, G., Danze, F., Jaisson, F., Rosa, R. Blood (1994) [Pubmed]
  6. Determinants essential for the transmissible gastroenteritis virus-receptor interaction reside within a domain of aminopeptidase-N that is distinct from the enzymatic site. Delmas, B., Gelfi, J., Kut, E., Sjöström, H., Noren, O., Laude, H. J. Virol. (1994) [Pubmed]
  7. Phosphorylation meets ubiquitination: the control of NF-[kappa]B activity. Karin, M., Ben-Neriah, Y. Annu. Rev. Immunol. (2000) [Pubmed]
  8. Signaling through the hematopoietic cytokine receptors. Ihle, J.N., Witthuhn, B.A., Quelle, F.W., Yamamoto, K., Silvennoinen, O. Annu. Rev. Immunol. (1995) [Pubmed]
  9. CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Trowbridge, I.S., Thomas, M.L. Annu. Rev. Immunol. (1994) [Pubmed]
  10. Still looking for the Ivory Tower. Schachman, H.K. Annu. Rev. Biochem. (2000) [Pubmed]
  11. The ATP synthase--a splendid molecular machine. Boyer, P.D. Annu. Rev. Biochem. (1997) [Pubmed]
  12. Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 A and the complex with tungstate. Stuckey, J.A., Schubert, H.L., Fauman, E.B., Zhang, Z.Y., Dixon, J.E., Saper, M.A. Nature (1994) [Pubmed]
  13. Signaling through estrogen receptors modulates telomerase activity in human prostate cancer. Nanni, S., Narducci, M., Della Pietra, L., Moretti, F., Grasselli, A., De Carli, P., Sacchi, A., Pontecorvi, A., Farsetti, A. J. Clin. Invest. (2002) [Pubmed]
  14. A GAF-domain-regulated adenylyl cyclase from Anabaena is a self-activating cAMP switch. Kanacher, T., Schultz, A., Linder, J.U., Schultz, J.E. EMBO J. (2002) [Pubmed]
  15. High-resolution structure of the E.coli RecQ helicase catalytic core. Bernstein, D.A., Zittel, M.C., Keck, J.L. EMBO J. (2003) [Pubmed]
  16. Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitors. Shih, C.K., Rose, J.M., Hansen, G.L., Wu, J.C., Bacolla, A., Griffin, J.A. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  17. A tyrosyl-tRNA synthetase recognizes a conserved tRNA-like structural motif in the group I intron catalytic core. Caprara, M.G., Lehnert, V., Lambowitz, A.M., Westhof, E. Cell (1996) [Pubmed]
  18. Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon. Meurs, E., Chong, K., Galabru, J., Thomas, N.S., Kerr, I.M., Williams, B.R., Hovanessian, A.G. Cell (1990) [Pubmed]
  19. The major cytoplasmic histone acetyltransferase in yeast: links to chromatin replication and histone metabolism. Parthun, M.R., Widom, J., Gottschling, D.E. Cell (1996) [Pubmed]
  20. pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo. Shelton, C.A., Wasserman, S.A. Cell (1993) [Pubmed]
  21. An inactivating point mutation in the inhibitory wedge of CD45 causes lymphoproliferation and autoimmunity. Majeti, R., Xu, Z., Parslow, T.G., Olson, J.L., Daikh, D.I., Killeen, N., Weiss, A. Cell (2000) [Pubmed]
  22. The structure and regulation of protein phosphatases. Cohen, P. Annu. Rev. Biochem. (1989) [Pubmed]
  23. Microinjection of p34cdc2 kinase induces marked changes in cell shape, cytoskeletal organization, and chromatin structure in mammalian fibroblasts. Lamb, N.J., Fernandez, A., Watrin, A., Labbé, J.C., Cavadore, J.C. Cell (1990) [Pubmed]
  24. A protein translocation defect linked to ubiquitin conjugation at the endoplasmic reticulum. Sommer, T., Jentsch, S. Nature (1993) [Pubmed]
  25. Fas-induced caspase denitrosylation. Mannick, J.B., Hausladen, A., Liu, L., Hess, D.T., Zeng, M., Miao, Q.X., Kane, L.S., Gow, A.J., Stamler, J.S. Science (1999) [Pubmed]
  26. Protein kinase injection reduces voltage-dependent potassium currents. Alkon, D.L., Acosta-Urquidi, J., Olds, J., Kuzma, G., Neary, J.T. Science (1983) [Pubmed]
  27. Globozoospermia in mice lacking the casein kinase II alpha' catalytic subunit. Xu, X., Toselli, P.A., Russell, L.D., Seldin, D.C. Nat. Genet. (1999) [Pubmed]
  28. A major step on the road to understanding a unique posttranslational modification and its role in a genetic disease. Baenziger, J.U. Cell (2003) [Pubmed]
  29. A gene encoding a protein serine/threonine kinase is required for normal development of M. xanthus, a gram-negative bacterium. Muñoz-Dorado, J., Inouye, S., Inouye, M. Cell (1991) [Pubmed]
  30. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85 alpha. Fruman, D.A., Mauvais-Jarvis, F., Pollard, D.A., Yballe, C.M., Brazil, D., Bronson, R.T., Kahn, C.R., Cantley, L.C. Nat. Genet. (2000) [Pubmed]
  31. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nakayama, J., Tahara, H., Tahara, E., Saito, M., Ito, K., Nakamura, H., Nakanishi, T., Tahara, E., Ide, T., Ishikawa, F. Nat. Genet. (1998) [Pubmed]
  32. PIK3CA is implicated as an oncogene in ovarian cancer. Shayesteh, L., Lu, Y., Kuo, W.L., Baldocchi, R., Godfrey, T., Collins, C., Pinkel, D., Powell, B., Mills, G.B., Gray, J.W. Nat. Genet. (1999) [Pubmed]
  33. Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Toda, T., Cameron, S., Sass, P., Zoller, M., Wigler, M. Cell (1987) [Pubmed]
  34. Initiation of meiosis in yeast mutants defective in adenylate cyclase and cyclic AMP-dependent protein kinase. Matsumoto, K., Uno, I., Ishikawa, T. Cell (1983) [Pubmed]
  35. Mutation of the matrix metalloproteinase 2 gene (MMP2) causes a multicentric osteolysis and arthritis syndrome. Martignetti, J.A., Aqeel, A.A., Sewairi, W.A., Boumah, C.E., Kambouris, M., Mayouf, S.A., Sheth, K.V., Eid, W.A., Dowling, O., Harris, J., Glucksman, M.J., Bahabri, S., Meyer, B.F., Desnick, R.J. Nat. Genet. (2001) [Pubmed]
  36. An early embryonic product of the gene shaggy encodes a serine/threonine protein kinase related to the CDC28/cdc2+ subfamily. Bourouis, M., Moore, P., Ruel, L., Grau, Y., Heitzler, P., Simpson, P. EMBO J. (1990) [Pubmed]
  37. Modulation of vimentin containing intermediate filament distribution and phosphorylation in living fibroblasts by the cAMP-dependent protein kinase. Lamb, N.J., Fernandez, A., Feramisco, J.R., Welch, W.J. J. Cell Biol. (1989) [Pubmed]
  38. Characterization of the minimal catalytic domain within eIF2B: the guanine-nucleotide exchange factor for translation initiation. Gomez, E., Mohammad, S.S., Pavitt, G.D. EMBO J. (2002) [Pubmed]
  39. Molecular characterization of functional domains in the protein kinase SOS2 that is required for plant salt tolerance. Guo, Y., Halfter, U., Ishitani, M., Zhu, J.K. Plant Cell (2001) [Pubmed]
  40. Crystal structure of the Escherichia coli thioesterase II, a homolog of the human Nef binding enzyme. Li, J., Derewenda, U., Dauter, Z., Smith, S., Derewenda, Z.S. Nat. Struct. Biol. (2000) [Pubmed]
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