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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ANLN  -  anillin, actin binding protein

Homo sapiens

Synonyms: ANILLIN, Actin-binding protein anillin, FSGS8, Scraps, scra
 
 
 
 
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Disease relevance of ANLN

  • Immunohistochemical staining of nuclear ANLN on lung cancer tissue microarrays was associated with the poor survival of NSCLC patients, indicating that this molecule might serve as a prognostic indicator [1].
 

Biological context of ANLN

  • Our data imply that up-regulation of ANLN is a common feature of the carcinogenetic process in lung tissue, and suggests that selective suppression of ANLN could be a promising approach for developing a new strategy to treat lung cancers [1].

References

  1. ANLN plays a critical role in human lung carcinogenesis through the activation of RHOA and by involvement in the phosphoinositide 3-kinase/AKT pathway. Suzuki, C., Daigo, Y., Ishikawa, N., Kato, T., Hayama, S., Ito, T., Tsuchiya, E., Nakamura, Y. Cancer Res. (2005) [Pubmed]
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