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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Up-Regulation


Psychiatry related information on Up-Regulation


High impact information on Up-Regulation

  • However, this upregulation in homeostatic regulatory mechanisms is not sufficient as these are unable to neutralize all the TNF alpha and IL-1 produced [11].
  • However, upregulation of Bcl-2 appears to be the normal mechanism for positive selection of developing lymphocytes, and its continued expression is critical for survival of mature peripheral B and T cells [12].
  • Measurements of leukotriene B4 (LTB4) production suggest that this risk is mediated through upregulation of the leukotriene pathway [13].
  • When neurons are stimulated by membrane depolarization, calcium signaling mediated by CaMKII induces dissociation of KIF4 from PARP-1, resulting in upregulation of PARP-1 activity, which supports neuron survival [14].
  • These studies provide evidence that environmental enrichment leads to reductions in steady-state levels of cerebral Abeta peptides and amyloid deposition and selective upregulation in levels of specific transcripts in brains of transgenic mice [15].

Chemical compound and disease context of Up-Regulation


Biological context of Up-Regulation


Anatomical context of Up-Regulation


Associations of Up-Regulation with chemical compounds


Gene context of Up-Regulation

  • Here we demonstrate that increased stability of Xist RNA is the primary determinant of developmental up-regulation [35].
  • Since aging increases promoter hypermethylation and epigenetic silencing of HIC1, we speculate that the resultant upregulation of SIRT1 may be a double-edged sword that both promotes survival of aging cells and increases cancer risk in mammals [36].
  • The upregulation of TGF-beta1 and integrin expression during wound healing has implicated these molecules in this process, but their precise regulation and roles remain unclear [37].
  • Here we show that oxidized phospholipids inhibit LPS-induced but not tumour-necrosis factor-alpha-induced or interleukin-1 beta-induced NF kappa B-mediated upregulation of inflammatory genes, by blocking the interaction of LPS with LPS-binding protein and CD14 [38].
  • Our results bring strong support to the hypothesis that muscle wasting in dystrophin-deficient DMD patients could be prevented by upregulation of utrophin [39].

Analytical, diagnostic and therapeutic context of Up-Regulation


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  16. Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion. Morigi, M., Angioletti, S., Imberti, B., Donadelli, R., Micheletti, G., Figliuzzi, M., Remuzzi, A., Zoja, C., Remuzzi, G. J. Clin. Invest. (1998) [Pubmed]
  17. Cholesterol 7-hydroxylase knockout mouse: a model for monohydroxy bile acid-related neonatal cholestasis. Arnon, R., Yoshimura, T., Reiss, A., Budai, K., Lefkowitch, J.H., Javitt, N.B. Gastroenterology (1998) [Pubmed]
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  19. Angiotensin II-induced hypertension increases heme oxygenase-1 expression in rat aorta. Ishizaka, N., de León, H., Laursen, J.B., Fukui, T., Wilcox, J.N., De Keulenaer, G., Griendling, K.K., Alexander, R.W. Circulation (1997) [Pubmed]
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  21. Ras1 promotes cellular growth in the Drosophila wing. Prober, D.A., Edgar, B.A. Cell (2000) [Pubmed]
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  23. Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development. Rudnicki, M.A., Braun, T., Hinuma, S., Jaenisch, R. Cell (1992) [Pubmed]
  24. Targeted mutagenesis of Tsix leads to nonrandom X inactivation. Lee, J.T., Lu, N. Cell (1999) [Pubmed]
  25. A mutation in the interferon-gamma-receptor gene and susceptibility to mycobacterial infection. Newport, M.J., Huxley, C.M., Huston, S., Hawrylowicz, C.M., Oostra, B.A., Williamson, R., Levin, M. N. Engl. J. Med. (1996) [Pubmed]
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  27. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Cheng, T., Liu, D., Griffin, J.H., Fernández, J.A., Castellino, F., Rosen, E.D., Fukudome, K., Zlokovic, B.V. Nat. Med. (2003) [Pubmed]
  28. Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents. St Croix, B., Flørenes, V.A., Rak, J.W., Flanagan, M., Bhattacharya, N., Slingerland, J.M., Kerbel, R.S. Nat. Med. (1996) [Pubmed]
  29. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Youssef, S., Stüve, O., Patarroyo, J.C., Ruiz, P.J., Radosevich, J.L., Hur, E.M., Bravo, M., Mitchell, D.J., Sobel, R.A., Steinman, L., Zamvil, S.S. Nature (2002) [Pubmed]
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  32. Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Burke, R., Nellen, D., Bellotto, M., Hafen, E., Senti, K.A., Dickson, B.J., Basler, K. Cell (1999) [Pubmed]
  33. Suppression of retinoic acid receptor-beta in premalignant oral lesions and its up-regulation by isotretinoin. Lotan, R., Xu, X.C., Lippman, S.M., Ro, J.Y., Lee, J.S., Lee, J.J., Hong, W.K. N. Engl. J. Med. (1995) [Pubmed]
  34. Epithelial secretion of C3 promotes colonization of the upper urinary tract by Escherichia coli. Springall, T., Sheerin, N.S., Abe, K., Holers, V.M., Wan, H., Sacks, S.H. Nat. Med. (2001) [Pubmed]
  35. Stabilization of Xist RNA mediates initiation of X chromosome inactivation. Sheardown, S.A., Duthie, S.M., Johnston, C.M., Newall, A.E., Formstone, E.J., Arkell, R.M., Nesterova, T.B., Alghisi, G.C., Rastan, S., Brockdorff, N. Cell (1997) [Pubmed]
  36. Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses. Chen, W.Y., Wang, D.H., Yen, R.C., Luo, J., Gu, W., Baylin, S.B. Cell (2005) [Pubmed]
  37. Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. Reynolds, L.E., Conti, F.J., Lucas, M., Grose, R., Robinson, S., Stone, M., Saunders, G., Dickson, C., Hynes, R.O., Lacy-Hulbert, A., Hodivala-Dilke, K. Nat. Med. (2005) [Pubmed]
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  39. Expression of truncated utrophin leads to major functional improvements in dystrophin-deficient muscles of mice. Deconinck, N., Tinsley, J., De Backer, F., Fisher, R., Kahn, D., Phelps, S., Davies, K., Gillis, J.M. Nat. Med. (1997) [Pubmed]
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