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Gene Review:

NEIL3 - nei endonuclease VIII-like 3 (E. coli)

Homo sapiens

Synonyms: DNA glycosylase FPG2, DNA glycosylase/AP lyase Neil3, Endonuclease 8-like 3, Endonuclease VIII-like 3, FGP2, ...

Rosenquist, T.A. et al., Zhang, Q.M. et al.

Rosenquist, Zaika, Fernandes, Zharkov, Miller, Grollman,

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Disease relevance of NEIL3

Recent works revealed that human cells have three orthologues of E. coli Nei, hNEIL1, hNEIL2 and hNEIL3 [1].

Biological context of NEIL3

Three human genes, designated NEIL1, NEIL2 and NEIL3, encode proteins that contain sequence homologies to Nei and Fpg [2].

References

DNA glycosylase activities for thymine residues oxidized in the methyl group are functions of the hNEIL1 and hNTH1 enzymes in human cells. Zhang, Q.M., Yonekura, S., Takao, M., Yasui, A., Sugiyama, H., Yonei, S. DNA Repair (Amst.) (2005) [Pubmed]
The novel DNA glycosylase, NEIL1, protects mammalian cells from radiation-mediated cell death. Rosenquist, T.A., Zaika, E., Fernandes, A.S., Zharkov, D.O., Miller, H., Grollman, A.P. DNA Repair (Amst.) (2003) [Pubmed]

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