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Gene Review:

PPP2R5A - protein phosphatase 2, regulatory subunit...

Homo sapiens

Synonyms: B56A, PP2A B subunit isoform B'-alpha, PP2A B subunit isoform B56-alpha, PP2A B subunit isoform PR61-alpha, PP2A B subunit isoform R5-alpha, ...

Yang, H.X. et al., McCright, B. et al.

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High impact information on PPP2R5A

Genes PPP2R5A-PPP2R5E encoding the phosphatase regulatory proteins B56alpha, B56beta, B56gamma, B56delta, and B56epsilon have now been mapped by fluorescence in situ hybridization to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12, respectively [1].
The co-immunoprecipitation also showed that NS specifically interacted with PPP2R5A [2].
One was an alpha isoform of human protein phosphatase 2 regulatory subunit B (B56) (PPP2R5A) and the other was a novel gene being highly homologous to the gene associated with spondylo paralysis [2].

Other interactions of PPP2R5A

CONCLUSION: NS and PPP2R5A interact in yeast and mammalian cells, respectively, which is helpful for addressing the function of NS in cancer development and progression [2].

References

Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12. McCright, B., Brothman, A.R., Virshup, D.M. Genomics (1996) [Pubmed]
Screening and identification of proteins interacting with nucleostemin. Yang, H.X., Jin, G.L., Meng, L., Zhang, J.Z., Liu, W.B., Shou, C.C. World J. Gastroenterol. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

ATB' GAMMA	Arabidopsis thaliana
AT3G21650	Arabidopsis thaliana
PPP2R5A	Bos taurus
PPP2R5A	Canis lupus familiaris
ppp2r5a	Danio rerio
PPP2R5A	Gallus gallus
PPP2R5A	Macaca mulatta
Ppp2r5a	Mus musculus
Os07g0274800	Oryza sativa Japonica Group
Os08g0122000	Oryza sativa Japonica Group
Os03g0844500	Oryza sativa Japonica Group
Os04g0485100	Oryza sativa Japonica Group
PPP2R5A	Pan troglodytes
Ppp2r5a	Rattus norvegicus
ppp2r5a	Xenopus (Silurana) tropicalis

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