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Gene Review:

ASXL2 - additional sex combs like transcriptional...

Homo sapiens

Synonyms: ASXH2, FLJ10898, KIAA1685

Katoh, M. et al., Katoh, M. et al.

Katoh, Katoh, Katoh, Katoh,

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Disease relevance of ASXL2

Exons 2-13 of the ASXL2 gene are fused to exons 1-14 of the MYST3 gene in a case of therapy-related myelodysplastic syndrome due to t(2;8)(p23.3;p11.2) [1].

High impact information on ASXL2

ASXL3 was a predicted cancer-associated gene, just like ASXL1 and ASXL2 [1].
Human ASXL2 gene, consisting of at least 13 exons, was mapped to human chromosome 2p23.3, one of recombination hot spots or fragile sites associated with carcinogenesis [2].
Here, we searched for ASXL1-related gene within the human genome by using bioinformatics, and identified the ASXL2 gene [2].
Nucleotide sequence of human ASXL2 cDNA was determined by assembling the nucleotide sequences of human EST AI797346, and partial cDNAs MGC44431 (BC042999) and KIAA1685 (AB051472) [2].

Associations of ASXL2 with chemical compounds

Proline-rich domain was located within the divergent region of ASXL3, but not within that of ASXL1 and ASXL2 [1].

References

Identification and characterization of ASXL3 gene in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2004) [Pubmed]
Identification and characterization of ASXL2 gene in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2003) [Pubmed]

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ASXL2	Bos taurus
ASXL2	Canis lupus familiaris
asxl2	Danio rerio
ASXL2	Gallus gallus
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Asxl2	Rattus norvegicus

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