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SLC29A3  -  solute carrier family 29 (equilibrative...

Homo sapiens

Synonyms: ENT3, Equilibrative nucleoside transporter 3, FLJ11160, HCLAP, HJCD, ...
 
 
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High impact information on SLC29A3

  • Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes [1].
  • The 475-residue human and mouse proteins, designated hENT3 and mENT3, respectively, are 73% identical in amino acid sequence and possess long N-terminal hydrophilic domains that bear typical (DE)XXXL(LI) endosomal/lysosomal targeting motifs [1].
  • This paper summarizes current knowledge of the family and reports on the identification of a novel mammalian ENT isoform, designated ENT3, from mouse and human tissues [2].
  • The ENT3 and ENT4 isoforms have more recently also been shown to be genuine nucleoside transporters [3].

References

  1. Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. Baldwin, S.A., Yao, S.Y., Hyde, R.J., Ng, A.M., Foppolo, S., Barnes, K., Ritzel, M.W., Cass, C.E., Young, J.D. J. Biol. Chem. (2005) [Pubmed]
  2. The ENT family of eukaryote nucleoside and nucleobase transporters: recent advances in the investigation of structure/function relationships and the identification of novel isoforms. Hyde, R.J., Cass, C.E., Young, J.D., Baldwin, S.A. Mol. Membr. Biol. (2001) [Pubmed]
  3. The equilibrative nucleoside transporter family, SLC29. Baldwin, S.A., Beal, P.R., Yao, S.Y., King, A.E., Cass, C.E., Young, J.D. Pflugers Arch. (2004) [Pubmed]
 
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