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Gene Review

SLC29A4  -  solute carrier family 29 (equilibrative...

Homo sapiens

Synonyms: ENT4, Equilibrative nucleoside transporter 4, FLJ34923, PMAT, PSEC0113, ...
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Disease relevance of SLC29A4

  • We hypothesize that ENT4, in addition to playing roles in cardiac serotonin transport, contributes to the regulation of extracellular adenosine concentrations, in particular under the acidotic conditions associated with ischemia [1].

High impact information on SLC29A4


Biological context of SLC29A4

  • Accordingly, we have developed a motif analysis tool for phylogenomics (Phylomat, that scans predicted proteome sets for proteins containing highly conserved amino acid motifs or domains for in silico analysis of the evolutionary history of these motifs/domains [4].

Anatomical context of SLC29A4


Associations of SLC29A4 with chemical compounds

  • However, alanine substitution at Glu(206) in TM5 abolished PMAT activity without affecting cell surface expression [2].
  • 4. In contrast, serotonin transport by ENT4 was relatively insensitive to pH [1].
  • ENT4-mediated nucleoside transport was adenosine selective, sodium independent and only weakly inhibited by the classical inhibitors of equilibrative nucleoside transport, dipyridamole, dilazep, and nitrobenzylthioinosine [1].
  • Synthesis and some first-row transition-metal complexes of the 1,2,4-triazole-based Bis(terdentate) ligands TsPMAT and PMAT [5].

Other interactions of SLC29A4


  1. Distribution and functional characterization of equilibrative nucleoside transporter-4, a novel cardiac adenosine transporter activated at acidic pH. Barnes, K., Dobrzynski, H., Foppolo, S., Beal, P.R., Ismat, F., Scullion, E.R., Sun, L., Tellez, J., Ritzel, M.W., Claycomb, W.C., Cass, C.E., Young, J.D., Billeter-Clark, R., Boyett, M.R., Baldwin, S.A. Circ. Res. (2006) [Pubmed]
  2. Molecular Determinants of Substrate Selectivity of a Novel Organic Cation Transporter (PMAT) in the SLC29 Family. Zhou, M., Xia, L., Engel, K., Wang, J. J. Biol. Chem. (2007) [Pubmed]
  3. Identification and characterization of a novel monoamine transporter in the human brain. Engel, K., Zhou, M., Wang, J. J. Biol. Chem. (2004) [Pubmed]
  4. Phylomat: an automated protein motif analysis tool for phylogenomics. Graham, W.V., Tcheng, D.K., Shirk, A.L., Attene-Ramos, M.S., Welge, M.E., Gaskins, H.R. J. Proteome Res. (2004) [Pubmed]
  5. Synthesis and some first-row transition-metal complexes of the 1,2,4-triazole-based Bis(terdentate) ligands TsPMAT and PMAT. Klingele, M.H., Moubaraki, B., Murray, K.S., Brooker, S. Chemistry (Weinheim an der Bergstrasse, Germany) (2005) [Pubmed]
  6. The equilibrative nucleoside transporter family, SLC29. Baldwin, S.A., Beal, P.R., Yao, S.Y., King, A.E., Cass, C.E., Young, J.D. Pflugers Arch. (2004) [Pubmed]
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