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Gene Review:

PRB4 - proline-rich protein BstNI subfamily 4

Homo sapiens

Synonyms: Basic salivary proline-rich protein 4, Parotid o protein, Salivary proline-rich protein II-1, Salivary proline-rich protein Po

Azen, E.A. et al.

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Disease relevance of PRB4

The genetically determined absence of the II-1 glycoprotein leads to altered in vitro binding of Streptococcus sanguis 10556 to salivary proteins, which suggests a biological consequence for null mutations of the PRB4 gene [1].

High impact information on PRB4

The Po protein and a glycoprotein (II-1) are encoded in the PRB4 gene, and both proteins are absent in the presence of a mutation in the PRB4M PO- allele that contains a single nt change (G--C) at the +1 invariant position of the intron 3 5'donor splice site [1].

References

PRB1, PRB2, and PRB4 coded polymorphisms among human salivary concanavalin-A binding, II-1, and Po proline-rich proteins. Azen, E.A., Amberger, E., Fisher, S., Prakobphol, A., Niece, R.L. Am. J. Hum. Genet. (1996) [Pubmed]

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