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Gene Review

KDM4D  -  lysine (K)-specific demethylase 4D

Homo sapiens

Synonyms: FLJ10251, JHDM3D, JMJD2D, JmjC domain-containing histone demethylation protein 3D, Jumonji domain-containing protein 2D, ...
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High impact information on JMJD2D

  • We found that JMJD2A and C demethylate tri- and dimethylated H3K9 and H3K36, whereas JMJD2D demethylates tri-, di-, and monomethylated H3K9 [1].
  • In addition, JMJD2D homologous genes within human genome sequences AP002383.3 and AP001264.4 were designated JMJD2E and JMJD2F, respectively [2].
  • 1. JMJD2D, JMJD2E and JMJD2F genes were clustered at human chromosome 11q21 [2].

Other interactions of JMJD2D

  • These facts strongly indicate that JMJD2D, JMJD2E and JMJD2F genes are locally triplicated retrotransposed elements derived from JMJD2 family gene [2].


  1. Diversity within the JMJD2 histone demethylase family. Shin, S., Janknecht, R. Biochem. Biophys. Res. Commun. (2007) [Pubmed]
  2. Identification and characterization of JMJD2 family genes in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2004) [Pubmed]
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