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Gene Review

NDC1  -  NDC1 transmembrane nucleoporin

Homo sapiens

Synonyms: FLJ10407, NET3, Nucleoporin NDC1, TMEM48, Transmembrane protein 48, ...
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High impact information on TMEM48

  • Depletion of hNDC1 from human HeLa cells interferes with the assembly of phenylalanine-glycine repeat Nups into NPCs [1].
  • Human NDC1 (hNDC1) likely possesses six transmembrane segments, and it is located at the nuclear pore wall [1].
  • Lastly, we bring together data from another study to demonstrate that the human homologue of NDC1 is the known inner nuclear membrane protein, NET3 [2].


  1. NDC1: a crucial membrane-integral nucleoporin of metazoan nuclear pore complexes. Stavru, F., Hülsmann, B.B., Spang, A., Hartmann, E., Cordes, V.C., Görlich, D. J. Cell Biol. (2006) [Pubmed]
  2. Topology of yeast Ndc1p: predictions for the human NDC1/NET3 homologue. Lau, C.K., Delmar, V.A., Forbes, D.J. The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology. (2006) [Pubmed]
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