The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • OMIM
  • SNPedia
  • UniProt
  • Ensembl
  • HGNC

Table of contents

About

Terms

 

Gene Review: 

UNC45A  -  unc-45 homolog A (C. elegans)

Homo sapiens

Synonyms: GC-UNC45, GCUNC-45, GCUNC45, IRO039700, Protein unc-45 homolog A, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on UNC45A

  • Overexpression and knockdown experiments show GCUNC-45 to be a positive factor in promoting PR function in the cell [1].
  • GCUNC-45, previously implicated in the activities of myosins, can interact in vivo and in vitro with both PR-A and PR-B and with hsp90 [1].
 

Associations of UNC45A with chemical compounds

  • GCUNC45 efficiently blocked the progression of progesterone receptor chaperoning in an in vitro functional system when Hsp90beta was used, but did so with much less efficacy when Hsp90alpha was used [2].

References

  1. GCUNC-45 is a novel regulator for the progesterone receptor/hsp90 chaperoning pathway. Chadli, A., Graham, J.D., Abel, M.G., Jackson, T.A., Gordon, D.F., Wood, W.M., Felts, S.J., Horwitz, K.B., Toft, D. Mol. Cell. Biol. (2006) [Pubmed]
  2. GCUNC45 is the first Hsp90 co-chaperone to show alpha/beta isoform specificity. Chadli, A., Felts, S.J., Toft, D.O. J. Biol. Chem. (2008) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities