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Gene Review

REXO4  -  REX4, RNA exonuclease 4 homolog (S....

Homo sapiens

Synonyms: Exonuclease XPMC2, PMC2, Prevents mitotic catastrophe 2 protein homolog, REX4, RNA exonuclease 4, ...
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Disease relevance of REXO4

  • In transient transfection assays using reporter constructs containing the EpRE, hPMC2 alone can slightly activate reporter in ER-negative MDA-MB-231 breast cancer cells [1].

High impact information on REXO4

  • The activation of QR gene activity by hPMC2 is enhanced in the presence of ER beta [1].
  • Here we report the identification of cDNA clones for human XPMC2H, its mapping to the tuberous sclerosis gene TSC1 region on 9q34, determination of genomic structure, and identification of several coding region polymorphisms [2].
  • Further studies are required to determine the requirement for cyclin D1 and XPMC2H in AII-induced cell-cycle progression and cellular proliferation in the adrenal [3].

Other interactions of REXO4

  • One of these protein factors, hPMC2 (human homolog of Xenopus gene which prevents mitotic catastrophe), directly binds to the EpRE and interacts with the ER in yeast genetic screening and in vitro assays [1].
  • Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1 [2].


  1. Identification and characterization of a novel factor that regulates quinone reductase gene transcriptional activity. Montano, M.M., Wittmann, B.M., Bianco, N.R. J. Biol. Chem. (2000) [Pubmed]
  2. Human XPMC2H: cDNA cloning, mapping to 9q34, genomic structure, and evaluation as TSC1. Kwiatkowska, J., Slomski, R., Jozwiak, S., Short, M.P., Kwiatkowski, D.J. Genomics (1997) [Pubmed]
  3. The application of high density microarray for analysis of mitogenic signaling and cell-cycle in the adrenal. Wang, C., Francis, R., Harirchian, S., Batlle, D., Mayhew, B., Bassett, M., Rainey, W.E., Pestell, R.G. Endocr. Res. (2000) [Pubmed]
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