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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Cell Proliferation

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Disease relevance of Cell Proliferation


Psychiatry related information on Cell Proliferation


High impact information on Cell Proliferation


Chemical compound and disease context of Cell Proliferation


Biological context of Cell Proliferation


Anatomical context of Cell Proliferation


Associations of Cell Proliferation with chemical compounds

  • XOptx2 stimulates bromodeoxyuridine incorporation, and XOptx2-induced eye enlargement is dependent on cellular proliferation [31].
  • Neomycin, which binds PIP2 and PIP, inhibits both thrombin-stimulated initiation of cell proliferation and 32P pI incorporation into at concentrations above 2 mM without affecting thrombin binding, thymidine uptake, or cellular protein synthesis [32].
  • Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation [26].
  • The results indicate that extracellular matrix recognition by the alpha 5 beta 1 integrin plays a role in the control of cell proliferation and suggest that a reduction of this fibronectin receptor may be responsible for the acquisition of anchorage independence by transformed cells [33].
  • Extracts of various bovine tissues, including pituitary, brain, liver and kidney, acted synergistically with cholera toxin in stimulating Schwann cell proliferation, although the increase in cyclic AMP induced by the mixture was not greater than that seen with cholera toxin alone [34].

Gene context of Cell Proliferation

  • We suggest that cell contact, TGF beta, and p53 all restrain cell proliferation through related Cdk inhibitors [35].
  • Disruption of telomerase activity in normal human cells slows cell proliferation, restricts cell lifespan, and alters the maintenance of the 3' single-stranded telomeric overhang without changing the rate of overall telomere shortening [36].
  • In vivo, mutant embryos do not exhibit increased apoptosis but show reduced cell proliferation accompanied by decreased expression of cyclin E and mdm-2, a regulator of p53 activity [37].
  • Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation [38].
  • Through its type 1 receptor (TNFR1), the cytokine TNF elicits an unusually wide range of biological responses, including inflammation, tumor necrosis, cell proliferation, differentiation, and apoptosis [39].

Analytical, diagnostic and therapeutic context of Cell Proliferation


  1. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Seoane, J., Le, H.V., Shen, L., Anderson, S.A., Massagué, J. Cell (2004) [Pubmed]
  2. The E2F transcription factor is a cellular target for the RB protein. Chellappan, S.P., Hiebert, S., Mudryj, M., Horowitz, J.M., Nevins, J.R. Cell (1991) [Pubmed]
  3. Cytoplasmic relocalization and inhibition of the cyclin-dependent kinase inhibitor p27(Kip1) by PKB/Akt-mediated phosphorylation in breast cancer. Viglietto, G., Motti, M.L., Bruni, P., Melillo, R.M., D'Alessio, A., Califano, D., Vinci, F., Chiappetta, G., Tsichlis, P., Bellacosa, A., Fusco, A., Santoro, M. Nat. Med. (2002) [Pubmed]
  4. Mammary hyperplasia and carcinoma in MMTV-cyclin D1 transgenic mice. Wang, T.C., Cardiff, R.D., Zukerberg, L., Lees, E., Arnold, A., Schmidt, E.V. Nature (1994) [Pubmed]
  5. Human herpesvirus KSHV encodes a constitutively active G-protein-coupled receptor linked to cell proliferation. Arvanitakis, L., Geras-Raaka, E., Varma, A., Gershengorn, M.C., Cesarman, E. Nature (1997) [Pubmed]
  6. Risk of papillary thyroid cancer in women in relation to smoking and alcohol consumption. Rossing, M.A., Cushing, K.L., Voigt, L.F., Wicklund, K.G., Daling, J.R. Epidemiology (Cambridge, Mass.) (2000) [Pubmed]
  7. Cognitive disorders and neurogenesis deficits in Huntington's disease mice are rescued by fluoxetine. Grote, H.E., Bull, N.D., Howard, M.L., van Dellen, A., Blakemore, C., Bartlett, P.F., Hannan, A.J. Eur. J. Neurosci. (2005) [Pubmed]
  8. Decreased hippocampal cell proliferation in R6/1 Huntington's mice. Lazic, S.E., Grote, H., Armstrong, R.J., Blakemore, C., Hannan, A.J., van Dellen, A., Barker, R.A. Neuroreport (2004) [Pubmed]
  9. Expression of ID family genes in the synovia from patients with rheumatoid arthritis. Sakurai, D., Yamaguchi, A., Tsuchiya, N., Yamamoto, K., Tokunaga, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  10. Behavioural alterations in rats induced by single prenatal exposure of haloperidol. Singh, K.P., Jaiswal, A.K., Singh, M., Bhattacharya, S.K. Indian J. Exp. Biol. (1998) [Pubmed]
  11. The CD40 antigen and its ligand. Banchereau, J., Bazan, F., Blanchard, D., Brière, F., Galizzi, J.P., van Kooten, C., Liu, Y.J., Rousset, F., Saeland, S. Annu. Rev. Immunol. (1994) [Pubmed]
  12. Mechanism of action and in vivo role of platelet-derived growth factor. Heldin, C.H., Westermark, B. Physiol. Rev. (1999) [Pubmed]
  13. Frequent somatic mutations of the transcription factor ATBF1 in human prostate cancer. Sun, X., Frierson, H.F., Chen, C., Li, C., Ran, Q., Otto, K.B., Cantarel, B.L., Cantarel, B.M., Vessella, R.L., Gao, A.C., Petros, J., Miura, Y., Simons, J.W., Dong, J.T. Nat. Genet. (2005) [Pubmed]
  14. The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Adhikary, S., Marinoni, F., Hock, A., Hulleman, E., Popov, N., Beier, R., Bernard, S., Quarto, M., Capra, M., Goettig, S., Kogel, U., Scheffner, M., Helin, K., Eilers, M. Cell (2005) [Pubmed]
  15. Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Dupont, S., Zacchigna, L., Cordenonsi, M., Soligo, S., Adorno, M., Rugge, M., Piccolo, S. Cell (2005) [Pubmed]
  16. Dopamine depletion impairs precursor cell proliferation in Parkinson disease. Höglinger, G.U., Rizk, P., Muriel, M.P., Duyckaerts, C., Oertel, W.H., Caille, I., Hirsch, E.C. Nat. Neurosci. (2004) [Pubmed]
  17. Assessment of hormone dependence of comedo ductal carcinoma in situ of the breast. Holland, P.A., Knox, W.F., Potten, C.S., Howell, A., Anderson, E., Baildam, A.D., Bundred, N.J. J. Natl. Cancer Inst. (1997) [Pubmed]
  18. Cell proliferation in human cutaneous squamous cell carcinoma. Friedland, A.M., Weinstein, G.D. J. Natl. Cancer Inst. (1977) [Pubmed]
  19. Effect of progesterone on cell proliferation in the MXT mouse hormone-sensitive mammary neoplasm. Kiss, R., Paridaens, R.J., Heuson, J.C., Danguy, A.J. J. Natl. Cancer Inst. (1986) [Pubmed]
  20. Effect of transient hypoxia on sensitivity to doxorubicin in human and murine cell lines. Luk, C.K., Veinot-Drebot, L., Tjan, E., Tannock, I.F. J. Natl. Cancer Inst. (1990) [Pubmed]
  21. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Parant, J., Chavez-Reyes, A., Little, N.A., Yan, W., Reinke, V., Jochemsen, A.G., Lozano, G. Nat. Genet. (2001) [Pubmed]
  22. Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6. Malumbres, M., Sotillo, R., Santamaría, D., Galán, J., Cerezo, A., Ortega, S., Dubus, P., Barbacid, M. Cell (2004) [Pubmed]
  23. Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia. Naski, M.C., Wang, Q., Xu, J., Ornitz, D.M. Nat. Genet. (1996) [Pubmed]
  24. The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Woods, D.F., Bryant, P.J. Cell (1991) [Pubmed]
  25. Cyclin E controls S phase progression and its down-regulation during Drosophila embryogenesis is required for the arrest of cell proliferation. Knoblich, J.A., Sauer, K., Jones, L., Richardson, H., Saint, R., Lehner, C.F. Cell (1994) [Pubmed]
  26. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation. Spivak-Kroizman, T., Lemmon, M.A., Dikic, I., Ladbury, J.E., Pinchasi, D., Huang, J., Jaye, M., Crumley, G., Schlessinger, J., Lax, I. Cell (1994) [Pubmed]
  27. E2F repression by C/EBPalpha is required for adipogenesis and granulopoiesis in vivo. Porse, B.T., Pedersen TA, n.u.l.l., Xu, X., Lindberg, B., Wewer, U.M., Friis-Hansen, L., Nerlov, C. Cell (2001) [Pubmed]
  28. Hypermyelination and demyelinating peripheral neuropathy in Pmp22-deficient mice. Adlkofer, K., Martini, R., Aguzzi, A., Zielasek, J., Toyka, K.V., Suter, U. Nat. Genet. (1995) [Pubmed]
  29. Microtubule stabilization by taxol inhibits initiation of DNA synthesis by thrombin and by epidermal growth factor. Crossin, K.L., Carney, D.H. Cell (1981) [Pubmed]
  30. Progesterone inhibits arterial smooth muscle cell proliferation. Lee, W.S., Harder, J.A., Yoshizumi, M., Lee, M.E., Haber, E. Nat. Med. (1997) [Pubmed]
  31. Giant eyes in Xenopus laevis by overexpression of XOptx2. Zuber, M.E., Perron, M., Philpott, A., Bang, A., Harris, W.A. Cell (1999) [Pubmed]
  32. Phosphoinositides in mitogenesis: neomycin inhibits thrombin-stimulated phosphoinositide turnover and initiation of cell proliferation. Carney, D.H., Scott, D.L., Gordon, E.A., LaBelle, E.F. Cell (1985) [Pubmed]
  33. Elevated levels of the alpha 5 beta 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Giancotti, F.G., Ruoslahti, E. Cell (1990) [Pubmed]
  34. Schwann cell growth factors. Raff, M.C., Abney, E., Brockes, J.P., Hornby-Smith, A. Cell (1978) [Pubmed]
  35. Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals. Polyak, K., Lee, M.H., Erdjument-Bromage, H., Koff, A., Roberts, J.M., Tempst, P., Massagué, J. Cell (1994) [Pubmed]
  36. Telomerase maintains telomere structure in normal human cells. Masutomi, K., Yu, E.Y., Khurts, S., Ben-Porath, I., Currier, J.L., Metz, G.B., Brooks, M.W., Kaneko, S., Murakami, S., DeCaprio, J.A., Weinberg, R.A., Stewart, S.A., Hahn, W.C. Cell (2003) [Pubmed]
  37. The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse. Hakem, R., de la Pompa, J.L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., Firpo, E., Hui, C.C., Roberts, J., Rossant, J., Mak, T.W. Cell (1996) [Pubmed]
  38. Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation. Miyazaki, T., Liu, Z.J., Kawahara, A., Minami, Y., Yamada, K., Tsujimoto, Y., Barsoumian, E.L., Permutter, R.M., Taniguchi, T. Cell (1995) [Pubmed]
  39. Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death. Liu, Z.G., Hsu, H., Goeddel, D.V., Karin, M. Cell (1996) [Pubmed]
  40. The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle. Goodrich, D.W., Wang, N.P., Qian, Y.W., Lee, E.Y., Lee, W.H. Cell (1991) [Pubmed]
  41. Protein synthesis, cell growth and oncogenesis. Rhoads, R.E. Curr. Opin. Cell Biol. (1991) [Pubmed]
  42. Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Goberdhan, D.C., Paricio, N., Goodman, E.C., Mlodzik, M., Wilson, C. Genes Dev. (1999) [Pubmed]
  43. Transforming growth factor beta 1 (TGF-beta 1) induced neutrophil recruitment to synovial tissues: implications for TGF-beta-driven synovial inflammation and hyperplasia. Fava, R.A., Olsen, N.J., Postlethwaite, A.E., Broadley, K.N., Davidson, J.M., Nanney, L.B., Lucas, C., Townes, A.S. J. Exp. Med. (1991) [Pubmed]
  44. Drug resistance-reversal strategies: comparison of experimental data with model predictions. Slate, D., Michelson, S. J. Natl. Cancer Inst. (1991) [Pubmed]
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