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Gene Review:

FANCM - Fanconi anemia, complementation group M

Homo sapiens

Synonyms: ATP-dependent RNA helicase FANCM, FAAP250, Fanconi anemia group M protein, Fanconi anemia-associated polypeptide of 250 kDa, KIAA1596, ...

Meetei, A.R. et al.

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Disease relevance of FANCM

Our data suggest an evolutionary link between Fanconi anemia-associated proteins and DNA repair; FANCM may act as an engine that translocates the Fanconi anemia core complex along DNA [1].

High impact information on FANCM

FANCM is essential for monoubiquitination of FANCD2 and becomes hyperphosphorylated in response to DNA damage [1].

References

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Meetei, A.R., Medhurst, A.L., Ling, C., Xue, Y., Singh, T.R., Bier, P., Steltenpool, J., Stone, S., Dokal, I., Mathew, C.G., Hoatlin, M., Joenje, H., de Winter, J.P., Wang, W. Nat. Genet. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

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