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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

DNA Repair

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Disease relevance of DNA Repair


Psychiatry related information on DNA Repair


High impact information on DNA Repair

  • Similarly, in long-patch base excision repair, a damaged nucleotide is displaced into a flap and removed by FEN1 [11].
  • The bacterial RecA protein and the recombinational DNA repair of stalled replication forks [12].
  • They absorb light and transmit the electromagnetic signal to the molecular clock using a pterin and flavin adenine dinucleotide (FAD) as chromophore/cofactors, and are evolutionarily conserved and structurally related to the DNA repair enzyme photolyase [13].
  • Second, in eukaryotes some or all of the subunits of transcription factor IIH (TFIIH) are required for nucleotide excision repair [14].
  • We conclude that one function of SIRT6 is to promote normal DNA repair, and that SIRT6 loss leads to abnormalities in mice that overlap with aging-associated degenerative processes [15].

Chemical compound and disease context of DNA Repair


Biological context of DNA Repair


Anatomical context of DNA Repair


Associations of DNA Repair with chemical compounds


Gene context of DNA Repair


Analytical, diagnostic and therapeutic context of DNA Repair


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  2. Transcription-coupled repair of 8-oxoguanine: requirement for XPG, TFIIH, and CSB and implications for Cockayne syndrome. Le Page, F., Kwoh, E.E., Avrutskaya, A., Gentil, A., Leadon, S.A., Sarasin, A., Cooper, P.K. Cell (2000) [Pubmed]
  3. EMSY links the BRCA2 pathway to sporadic breast and ovarian cancer. Hughes-Davies, L., Huntsman, D., Ruas, M., Fuks, F., Bye, J., Chin, S.F., Milner, J., Brown, L.A., Hsu, F., Gilks, B., Nielsen, T., Schulzer, M., Chia, S., Ragaz, J., Cahn, A., Linger, L., Ozdag, H., Cattaneo, E., Jordanova, E.S., Schuuring, E., Yu, D.S., Venkitaraman, A., Ponder, B., Doherty, A., Aparicio, S., Bentley, D., Theillet, C., Ponting, C.P., Caldas, C., Kouzarides, T. Cell (2003) [Pubmed]
  4. Atomic model of a pyrimidine dimer excision repair enzyme complexed with a DNA substrate: structural basis for damaged DNA recognition. Vassylyev, D.G., Kashiwagi, T., Mikami, Y., Ariyoshi, M., Iwai, S., Ohtsuka, E., Morikawa, K. Cell (1995) [Pubmed]
  5. The DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents. Quinn, D.I. N. Engl. J. Med. (2001) [Pubmed]
  6. A role of the C-terminal part of p44 in the promoter escape activity of transcription factor IIH. Tremeau-Bravard, A., Perez, C., Egly, J.M. J. Biol. Chem. (2001) [Pubmed]
  7. Mycobacterium bovis BCG recA deletion mutant shows increased susceptibility to DNA-damaging agents but wild-type survival in a mouse infection model. Sander, P., Papavinasasundaram, K.G., Dick, T., Stavropoulos, E., Ellrott, K., Springer, B., Colston, M.J., Böttger, E.C. Infect. Immun. (2001) [Pubmed]
  8. Damage and repair of nerve cell DNA in toxic stress. Kisby, G.E., Kabel, H., Hugon, J., Spencer, P. Drug Metab. Rev. (1999) [Pubmed]
  9. DNA damage and chronic neuronal degenerations. Robison, S.H., Bradley, W.G. J. Neurol. Sci. (1984) [Pubmed]
  10. Reactive nitrogen species in colon carcinogenesis. Payne, C.M., Bernstein, C., Bernstein, H., Gerner, E.W., Garewal, H. Antioxid. Redox Signal. (1999) [Pubmed]
  11. Flap endonuclease 1: a central component of DNA metabolism. Liu, Y., Kao, H.I., Bambara, R.A. Annu. Rev. Biochem. (2004) [Pubmed]
  12. The bacterial RecA protein and the recombinational DNA repair of stalled replication forks. Lusetti, S.L., Cox, M.M. Annu. Rev. Biochem. (2002) [Pubmed]
  13. Cryptochrome: the second photoactive pigment in the eye and its role in circadian photoreception. Sancar, A. Annu. Rev. Biochem. (2000) [Pubmed]
  14. Relationships between DNA repair and transcription. Friedberg, E.C. Annu. Rev. Biochem. (1996) [Pubmed]
  15. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Mostoslavsky, R., Chua, K.F., Lombard, D.B., Pang, W.W., Fischer, M.R., Gellon, L., Liu, P., Mostoslavsky, G., Franco, S., Murphy, M.M., Mills, K.D., Patel, P., Hsu, J.T., Hong, A.L., Ford, E., Cheng, H.L., Kennedy, C., Nunez, N., Bronson, R., Frendewey, D., Auerbach, W., Valenzuela, D., Karow, M., Hottiger, M.O., Hursting, S., Barrett, J.C., Guarente, L., Mulligan, R., Demple, B., Yancopoulos, G.D., Alt, F.W. Cell (2006) [Pubmed]
  16. Formation of Okazaki fragments in polyoma DNA synthesis caused by misincorporation of uracil. Brynolf, K., Eliasson, R., Reichard, P. Cell (1978) [Pubmed]
  17. Three-dimensional structure of a DNA repair enzyme, 3-methyladenine DNA glycosylase II, from Escherichia coli. Yamagata, Y., Kato, M., Odawara, K., Tokuno, Y., Nakashima, Y., Matsushima, N., Yasumura, K., Tomita, K., Ihara, K., Fujii, Y., Nakabeppu, Y., Sekiguchi, M., Fujii, S. Cell (1996) [Pubmed]
  18. Effect of glutathione on DNA repair in cisplatin-resistant human ovarian cancer cell lines. Lai, G.M., Ozols, R.F., Young, R.C., Hamilton, T.C. J. Natl. Cancer Inst. (1989) [Pubmed]
  19. UvrAB activity at a damaged DNA site: is unpaired DNA present? Gordienko, I., Rupp, W.D. EMBO J. (1997) [Pubmed]
  20. The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells. Chen, Q., Van der Sluis, P.C., Boulware, D., Hazlehurst, L.A., Dalton, W.S. Blood (2005) [Pubmed]
  21. BRCA1 induces DNA damage recognition factors and enhances nucleotide excision repair. Hartman, A.R., Ford, J.M. Nat. Genet. (2002) [Pubmed]
  22. Involvement of the TIP60 histone acetylase complex in DNA repair and apoptosis. Ikura, T., Ogryzko, V.V., Grigoriev, M., Groisman, R., Wang, J., Horikoshi, M., Scully, R., Qin, J., Nakatani, Y. Cell (2000) [Pubmed]
  23. Crystal structure and ATPase activity of MutL: implications for DNA repair and mutagenesis. Ban, C., Yang, W. Cell (1998) [Pubmed]
  24. Analysis of wild-type and rad50 mutants of yeast suggests an intimate relationship between meiotic chromosome synapsis and recombination. Alani, E., Padmore, R., Kleckner, N. Cell (1990) [Pubmed]
  25. Genetic interaction between PARP and DNA-PK in V(D)J recombination and tumorigenesis. Morrison, C., Smith, G.C., Stingl, L., Jackson, S.P., Wagner, E.F., Wang, Z.Q. Nat. Genet. (1997) [Pubmed]
  26. Mice with DNA repair gene (ERCC-1) deficiency have elevated levels of p53, liver nuclear abnormalities and die before weaning. McWhir, J., Selfridge, J., Harrison, D.J., Squires, S., Melton, D.W. Nat. Genet. (1993) [Pubmed]
  27. The C termini of Arabidopsis cryptochromes mediate a constitutive light response. Yang, H.Q., Wu, Y.J., Tang, R.H., Liu, D., Liu, Y., Cashmore, A.R. Cell (2000) [Pubmed]
  28. Human xeroderma pigmentosum group D gene encodes a DNA helicase. Sung, P., Bailly, V., Weber, C., Thompson, L.H., Prakash, L., Prakash, S. Nature (1993) [Pubmed]
  29. Complementation of the DNA repair defect in xeroderma pigmentosum group G cells by a human cDNA related to yeast RAD2. Scherly, D., Nouspikel, T., Corlet, J., Ucla, C., Bairoch, A., Clarkson, S.G. Nature (1993) [Pubmed]
  30. Crystal structure of a G:T/U mismatch-specific DNA glycosylase: mismatch recognition by complementary-strand interactions. Barrett, T.E., Savva, R., Panayotou, G., Barlow, T., Brown, T., Jiricny, J., Pearl, L.H. Cell (1998) [Pubmed]
  31. Defective DNA-dependent protein kinase activity is linked to V(D)J recombination and DNA repair defects associated with the murine scid mutation. Blunt, T., Finnie, N.J., Taccioli, G.E., Smith, G.C., Demengeot, J., Gottlieb, T.M., Mizuta, R., Varghese, A.J., Alt, F.W., Jeggo, P.A. Cell (1995) [Pubmed]
  32. Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA. Kastan, M.B., Gowans, B.J., Lieberman, M.W. Cell (1982) [Pubmed]
  33. Crystal structure of a SIR2 homolog-NAD complex. Min, J., Landry, J., Sternglanz, R., Xu, R.M. Cell (2001) [Pubmed]
  34. p53 modulation of TFIIH-associated nucleotide excision repair activity. Wang, X.W., Yeh, H., Schaeffer, L., Roy, R., Moncollin, V., Egly, J.M., Wang, Z., Freidberg, E.C., Evans, M.K., Taffe, B.G. Nat. Genet. (1995) [Pubmed]
  35. BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function. Cantor, S.B., Bell, D.W., Ganesan, S., Kass, E.M., Drapkin, R., Grossman, S., Wahrer, D.C., Sgroi, D.C., Lane, W.S., Haber, D.A., Livingston, D.M. Cell (2001) [Pubmed]
  36. Dual roles of a multiprotein complex from S. cerevisiae in transcription and DNA repair. Feaver, W.J., Svejstrup, J.Q., Bardwell, L., Bardwell, A.J., Buratowski, S., Gulyas, K.D., Donahue, T.F., Friedberg, E.C., Kornberg, R.D. Cell (1993) [Pubmed]
  37. UV irradiation triggers ubiquitin-dependent degradation of p21(WAF1) to promote DNA repair. Bendjennat, M., Boulaire, J., Jascur, T., Brickner, H., Barbier, V., Sarasin, A., Fotedar, A., Fotedar, R. Cell (2003) [Pubmed]
  38. INO80 and gamma-H2AX interaction links ATP-dependent chromatin remodeling to DNA damage repair. Morrison, A.J., Highland, J., Krogan, N.J., Arbel-Eden, A., Greenblatt, J.F., Haber, J.E., Shen, X. Cell (2004) [Pubmed]
  39. Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Pagano, M., Theodoras, A.M., Tam, S.W., Draetta, G.F. Genes Dev. (1994) [Pubmed]
  40. Identification of promoters bound by c-Jun/ATF2 during rapid large-scale gene activation following genotoxic stress. Hayakawa, J., Mittal, S., Wang, Y., Korkmaz, K.S., Adamson, E., English, C., Ohmichi, M., Omichi, M., McClelland, M., Mercola, D. Mol. Cell (2004) [Pubmed]
  41. Lability of DNA polymerase alpha correlated with decreased DNA synthesis and increased age in human cells. Busbee, D., Sylvia, V., Stec, J., Cernosek, Z., Norman, J. J. Natl. Cancer Inst. (1987) [Pubmed]
  42. Increased DNA synthesis and repair-enzyme expression in lymphocytes from patients with chronic lymphocytic leukemia resistant to nitrogen mustards. Geleziunas, R., McQuillan, A., Malapetsa, A., Hutchinson, M., Kopriva, D., Wainberg, M.A., Hiscott, J., Bramson, J., Panasci, L. J. Natl. Cancer Inst. (1991) [Pubmed]
  43. Changes in cyclin/proliferating cell nuclear antigen distribution during DNA repair synthesis. Toschi, L., Bravo, R. J. Cell Biol. (1988) [Pubmed]
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