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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

ANKRA2  -  ankyrin repeat, family A (RFXANK-like), 2

Homo sapiens

Synonyms: ANKRA, Ankyrin repeat family A protein 2, RFXANK-like protein 2
 
 
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High impact information on ANKRA2

  • We discovered that ANKRA2, the closest paralogue of RFXANK, can substitute for RFXANK in the activation of MHC-II genes and that this ability is mediated by its ankyrin repeat domain (ARD) [1].
  • In addition to sequence conservation, functional conservation exists, as mouse and Xenopus RFX-B orthologues, but not the paralogous protein ANKRA2, were able to complement the MHC II deficiency in a BLS-patient-derived cell line deficient in RFX-B [2].

References

  1. New functions of the major histocompatibility complex class II-specific transcription factor RFXANK revealed by a high-resolution mutagenesis study. Krawczyk, M., Masternak, K., Zufferey, M., Barras, E., Reith, W. Mol. Cell. Biol. (2005) [Pubmed]
  2. Evolutionary conservation and characterization of the bare lymphocyte syndrome transcription factor RFX-B and its paralogue ANKRA2. Long, A.B., Boss, J.M. Immunogenetics (2005) [Pubmed]
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