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Sertad2  -  SERTA domain containing 2

Mus musculus

Synonyms: AB041541, AU021878, Kiaa0127, MNCb-1504, SEI-2, ...
 
 
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High impact information on Sertad2

  • Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance [1].
  • TRIP-Br2-null mice are resistant to obesity and obesity-related insulin resistance.
  • Adipocytes of these knockout mice showed greater stimulated lipolysis secondary to enhanced expression of hormone sensitive lipase (HSL) and β3-adrenergic (Adrb3) receptors.
  • The knockout mice also have higher energy expenditure because of increased adipocyte thermogenesis and oxidative metabolism caused by upregulating key enzymes in their respective processes.
  • Collectively, TRIP-Br2, modulates fat storage through simultaneous regulation of lipolysis, thermogenesis andoxidative metabolism.
  • TRIP-Br2 expression is selectively elevated in visceral fat in obese humans , suggests that this transcriptional co-regulator is a new therapeutic target for counteracting the development of obesity, insulin resistance andhyperlipidemia.
  • TRIP-Br1 and the related protein TRIP-Br2 possess transactivation domains [2].
  • We conclude that both TRIP-Br1 and TRIP-Br2 are required for proper transduction of mitogenic signals and execution of serum-inducible cell cycle progression [3].

References

  1. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Liew, C.W., Boucher, J., Cheong, J.K., Vernochet, C., Koh, H.J., Mallol, C., Townsend, K., Langin, D., Kawamori, D., Hu, J., Tseng, Y.H., Hellerstein, M.K., Farmer, S.R., Goodyear, L., Doria, A., Blüher, M., Hsu, S.I., Kulkarni, R.N. Nat. Med. (2013) [Pubmed]
  2. TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. Hsu, S.I., Yang, C.M., Sim, K.G., Hentschel, D.M., O'Leary, E., Bonventre, J.V. EMBO J. (2001) [Pubmed]
  3. The TRIP-Br family of transcriptional regulators is essential for the execution of cyclin E-mediated cell cycle progression. Sim, K.G., Cheong, J.K., Hsu, S.I. Cell Cycle (2006) [Pubmed]
 
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