Gene Review:
SERTAD2 - SERTA domain containing 2
Homo sapiens
Synonyms:
KIAA0127, SERTA domain-containing protein 2, Sei-2, TRIP-Br2, Transcriptional regulator interacting with the PHD-bromodomain 2
- Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Liew, C.W., Boucher, J., Cheong, J.K., Vernochet, C., Koh, H.J., Mallol, C., Townsend, K., Langin, D., Kawamori, D., Hu, J., Tseng, Y.H., Hellerstein, M.K., Farmer, S.R., Goodyear, L., Doria, A., Blüher, M., Hsu, S.I., Kulkarni, R.N. Nat. Med. (2013)
- TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors. Cheong, J.K., Gunaratnam, L., Zang, Z.J., Yang, C.M., Sun, X., Nasr, S.L., Sim, K.G., Peh, B.K., Rashid, S.B., Bonventre, J.V., Salto-Tellez, M., Hsu, S.I. J. Transl. Med. (2009)
- TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. Hsu, S.I., Yang, C.M., Sim, K.G., Hentschel, D.M., O'Leary, E., Bonventre, J.V. EMBO. J. (2001)
- The TRIP-Br family of transcriptional regulators is essential for the execution of cyclin E-mediated cell cycle progression. Sim, K.G., Cheong, J.K., Hsu, S.I. Cell. Cycle. (2006)
- CRM1-mediated nuclear export is required for 26 S proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein. Cheong, J.K., Gunaratnam, L., Hsu, S.I. J. Biol. Chem. (2008)
- CDCA4 Is an E2F Transcription Factor Family-induced Nuclear Factor That Regulates E2F-dependent Transcriptional Activation and Cell Proliferation. Hayashi, R., Goto, Y., Ikeda, R., Yokoyama, K.K., Yoshida, K. J. Biol. Chem. (2006)
- Celecoxib reduces microvessel density in patients treated with nasopharyngeal carcinoma and induces changes in gene expression. Soo, R., Wu, J., Aggarwal, A., Tao, Q., Hsieh, W., Putti, T., Tan, K., Soon, W., Lai, Y., Mow, B., Hsu, S., Loh, K., Tan, L., Tan, P., Goh, B.C. Ann. Oncol. (2006)
- TRIP-Br links E2F to novel functions in the regulation of cyclin E expression during cell cycle progression and in the maintenance of genomic stability. Sim, K.G., Zang, Z., Yang, C.M., Bonventre, J.V., Hsu, S.I. Cell Cycle (2004)
- I-mfa domain proteins specifically interact with SERTA domain proteins and repress their transactivating functions. Kusano, S., Shiimura, Y., Eizuru, Y. Biochimie. (2011)