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Gene Review

RABIF  -  RAB interacting factor

Homo sapiens

Synonyms: Guanine nucleotide exchange factor MSS4, MSS4, RASGFR3, RASGRF3, Rab-interacting factor, ...
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Disease relevance of RABIF


High impact information on RABIF

  • As expected, both the cDNA and its encoded amino acid sequences are highly conserved between the human and rat mss4 [2].
  • A search of the DNA databases showed that two proteins from Saccharomyces cerevisiae shared close similarity to this enzyme, one of which, the mss4 gene product, has been implicated in the yeast inositol lipid pathway [3].


  1. Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer. Müller-Pillasch, F., Zimmerhackl, F., Lacher, U., Schultz, N., Hameister, H., Varga, G., Friess, H., Büchler, M., Adler, G., Gress, T.M. Genomics (1997) [Pubmed]
  2. Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4. Yu, H., Schreiber, S.L. Biochemistry (1995) [Pubmed]
  3. The cloning and sequence of the C isoform of PtdIns4P 5-kinase. Divecha, N., Truong, O., Hsuan, J.J., Hinchliffe, K.A., Irvine, R.F. Biochem. J. (1995) [Pubmed]
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