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Gene Review

FNDC3B  -  fibronectin type III domain containing 3B

Homo sapiens

Synonyms: DKFZp762K137, FAD104, FLJ23399, Factor for adipocyte differentiation 104, Fibronectin type III domain-containing protein 3B, ...
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High impact information on FNDC3B

  • FAD104 had weaker activity than DOX in DNA single and double strand scission in P388 cells and in binding to calf thymus DNA [1].
  • From various new anthracyclines containing fluorine in their sugar moieties, 7-O-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl)adriamycinone-14-hemi pimerate (FAD104) has been selected for clinical investigation, because of its excellent antitumor activity and solubility [1].
  • Doxorubicin, pirarubicin, and FAD-104, but not aclarubicin or MX 2, flattened the morphology of NIH3T3 cells that had been transformed by human H-ras and K-ras [2].

Associations of FNDC3B with chemical compounds


  1. Biological activities of new anthracyclines containing fluorine, FAD104 and its metabolites. Kunimoto, S., Komuro, K., Nosaka, C., Tsuchiya, T., Fukatsu, S., Takeuchi, T. J. Antibiot. (1990) [Pubmed]
  2. Distinct effects of clinically used anthracycline antibiotics on ras oncogene-expressed cells. Tsuchiya, K.S., Kanbe, T., Hori, M., Uehara, Y., Takahashi, Y., Takeuchi, T. Biol. Pharm. Bull. (1993) [Pubmed]
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