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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

GINS3  -  GINS complex subunit 3 (Psf3 homolog)

Homo sapiens

Synonyms: DNA replication complex GINS protein PSF3, FLJ13912, GINS complex subunit 3, PSF3
 
 
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High impact information on GINS3

  • Phylogenetic comparisons with other Alu sequences reveal that the YAP element is a member of the polymorphic subfamily-3 (PSF-3), a previously undefined subfamily of Alu elements [1].
  • Reporter gene assay using putative GINS promoter sequences revealed that the expression of mammalian GINS is regulated by 17beta-Estradiol-stimulated estrogen receptor alpha, and human PSF3 acts as a gene responsive to transcription factor E2F1 [2].

References

  1. A recent insertion of an alu element on the Y chromosome is a useful marker for human population studies. Hammer, M.F. Mol. Biol. Evol. (1994) [Pubmed]
  2. A Combined Computational and Experimental Study on the Structure-Regulation Relationships of Putative Mammalian DNA Replication Initiator GINS. Hayashi, R., Arauchi, T., Tategu, M., Goto, Y., Yoshida, K. Genomics Proteomics Bioinformatics (2006) [Pubmed]
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