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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, Reporter

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Disease relevance of Genes, Reporter


Psychiatry related information on Genes, Reporter


High impact information on Genes, Reporter

  • Reporter-gene studies using a minimal PTF1A deletion mutant indicate that the deleted region defines a new domain that is crucial for the function of this protein [7].
  • We used a targeted enhancer-trap approach to identify a DNA segment capable of directing reporter gene expression in both digits and CNS, following Lnp, Evx2, and Hoxd-specific patterns [8].
  • This sequence element bound to p53 and conferred p53-dependent inducibility on a heterologous reporter gene [9].
  • Luciferase reporter gene assays show that CLOCK-BMAL1 heterodimers act through an E box enhancer in the vasopressin gene to activate transcription; this activation can be inhibited by the mPER and mTIM proteins [10].
  • Furthermore, ectopic expression of Sox9 trans-activates both a COL2A1-driven reporter gene and the endogenous Col2a1 gene in transgenic mice [11].

Chemical compound and disease context of Genes, Reporter


Biological context of Genes, Reporter


Anatomical context of Genes, Reporter


Associations of Genes, Reporter with chemical compounds

  • A steroid hormone responsive element (GRE/PRE), sufficient to confer glucocorticoid and progesterone inducibility when linked to a reporter gene, was used in band-shift assays to examine its molecular interactions with steroid hormone receptors [27].
  • Overexpression of SREBP-1 activates transcription of reporter genes containing SRE-1 in the absence (15-fold) and presence (90-fold) of sterols, abolishing sterol regulation [28].
  • We have found that a polyglutamine (Gln) expanded AR transactivates an androgen-responsive reporter gene subnormally [29].
  • The mSin3A immunocomplexes possess histone deacetylase activity that is sensitive to the specific deacetylase inhibitor trapoxin. mSin3A-targeted repression of a reporter gene is reduced by trapoxin treatment, suggesting that histone deacetylation mediates transcriptional repression through Mad-Max-mSin3A multimeric complexes [30].
  • Here we show that retinoic acid (RA) at physiological concentrations is effective in inducing the expression of this reporter gene by the hap-ER chimaeric receptor [31].

Gene context of Genes, Reporter

  • Both the N-terminal A/B region and the hormone binding domain of ER were involved in this inhibition, which was antagonized by antiestrogens and did not appear to involve direct interaction between ER and either reporter gene or PR [32].
  • We used a HIS3 reporter gene to show that RNA-mediated recombination occurs in yeast [33].
  • An internally deleted nonfunctional cln2 gene was used as a reporter gene to demonstrate that in the absence of mating pheromone, efficient expression of cln2 mRNA requires both an active CDC28 gene and at least one functional CLN gene. mRNA from a nonfunctional cln1 gene was regulated similarly [34].
  • Overexpression of CHUK activates a NF-kappaB-dependent reporter gene [35].
  • A Hoxd-11/lacz reporter gene replaced the deleted region in order to monitor the effect of this triple inactivation at the cellular level [36].

Analytical, diagnostic and therapeutic context of Genes, Reporter


  1. Transcriptional but not translational regulation of HIV-1 by the tat gene product. Rice, A.P., Mathews, M.B. Nature (1988) [Pubmed]
  2. Temporal and spatial regulation of the symbiotic genes of Rhizobium meliloti in planta revealed by transposon Tn5-gusA. Sharma, S.B., Signer, E.R. Genes Dev. (1990) [Pubmed]
  3. Selective transgene expression for detection and elimination of contaminating carcinoma cells in hematopoietic stem cell sources. Chen, L., Pulsipher, M., Chen, D., Sieff, C., Elias, A., Fine, H.A., Kufe, D.W. J. Clin. Invest. (1996) [Pubmed]
  4. Retrovirus vector silencing is de novo methylase independent and marked by a repressive histone code. Pannell, D., Osborne, C.S., Yao, S., Sukonnik, T., Pasceri, P., Karaiskakis, A., Okano, M., Li, E., Lipshitz, H.D., Ellis, J. EMBO J. (2000) [Pubmed]
  5. The protein encoded by oncogene 6b from Agrobacterium tumefaciens interacts with a nuclear protein of tobacco. Kitakura, S., Fujita, T., Ueno, Y., Terakura, S., Wabiko, H., Machida, Y. Plant Cell (2002) [Pubmed]
  6. Antagonistic properties of human prolactin analogs that show paradoxical agonistic activity in the Nb2 bioassay. Goffin, V., Kinet, S., Ferrag, F., Binart, N., Martial, J.A., Kelly, P.A. J. Biol. Chem. (1996) [Pubmed]
  7. Mutations in PTF1A cause pancreatic and cerebellar agenesis. Sellick, G.S., Barker, K.T., Stolte-Dijkstra, I., Fleischmann, C., Coleman, R.J., Garrett, C., Gloyn, A.L., Edghill, E.L., Hattersley, A.T., Wellauer, P.K., Goodwin, G., Houlston, R.S. Nat. Genet. (2004) [Pubmed]
  8. A global control region defines a chromosomal regulatory landscape containing the HoxD cluster. Spitz, F., Gonzalez, F., Duboule, D. Cell (2003) [Pubmed]
  9. Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis. Lin, Y., Ma, W., Benchimol, S. Nat. Genet. (2000) [Pubmed]
  10. A molecular mechanism regulating rhythmic output from the suprachiasmatic circadian clock. Jin, X., Shearman, L.P., Weaver, D.R., Zylka, M.J., de Vries, G.J., Reppert, S.M. Cell (1999) [Pubmed]
  11. SOX9 directly regulates the type-II collagen gene. Bell, D.M., Leung, K.K., Wheatley, S.C., Ng, L.J., Zhou, S., Ling, K.W., Sham, M.H., Koopman, P., Tam, P.P., Cheah, K.S. Nat. Genet. (1997) [Pubmed]
  12. Apolipoprotein E deficiency in mice: gene replacement and prevention of atherosclerosis using adenovirus vectors. Kashyap, V.S., Santamarina-Fojo, S., Brown, D.R., Parrott, C.L., Applebaum-Bowden, D., Meyn, S., Talley, G., Paigen, B., Maeda, N., Brewer, H.B. J. Clin. Invest. (1995) [Pubmed]
  13. Resveratrol, a polyphenolic compound found in grapes and wine, is an agonist for the estrogen receptor. Gehm, B.D., McAndrews, J.M., Chien, P.Y., Jameson, J.L. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  14. Repressor to activator switch by mutations in the first Zn finger of the glucocorticoid receptor: is direct DNA binding necessary? Ray, A., LaForge, K.S., Sehgal, P.B. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  15. Overexpression of the human VPAC2 receptor in the suprachiasmatic nucleus alters the circadian phenotype of mice. Shen, S., Spratt, C., Sheward, W.J., Kallo, I., West, K., Morrison, C.F., Coen, C.W., Marston, H.M., Harmar, A.J. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  16. Negative regulation of the thyroid-stimulating hormone alpha gene by thyroid hormone: receptor interaction adjacent to the TATA box. Chatterjee, V.K., Lee, J.K., Rentoumis, A., Jameson, J.L. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  17. Reactivation of thyroglobulin gene expression in transformed thyroid cells by 5-azacytidine. Avvedimento, E.V., Obici, S., Sanchez, M., Gallo, A., Musti, A., Gottesman, M.E. Cell (1989) [Pubmed]
  18. Tumor suppressor p53 is a direct transcriptional activator of the human bax gene. Miyashita, T., Reed, J.C. Cell (1995) [Pubmed]
  19. Developmental expression pattern screen for genes predicted in the C. elegans genome sequencing project. Lynch, A.S., Briggs, D., Hope, I.A. Nat. Genet. (1995) [Pubmed]
  20. Transcriptional activation by the v-myb oncogene and its cellular progenitor, c-myb. Weston, K., Bishop, J.M. Cell (1989) [Pubmed]
  21. A 5' element of the chicken beta-globin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Chung, J.H., Whiteley, M., Felsenfeld, G. Cell (1993) [Pubmed]
  22. Trypanosome invasion of mammalian cells requires activation of the TGF beta signaling pathway. Ming, M., Ewen, M.E., Pereira, M.E. Cell (1995) [Pubmed]
  23. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Mangi, A.A., Noiseux, N., Kong, D., He, H., Rezvani, M., Ingwall, J.S., Dzau, V.J. Nat. Med. (2003) [Pubmed]
  24. Control of neuronal pathway selection by a Drosophila receptor protein-tyrosine kinase family member. Callahan, C.A., Muralidhar, M.G., Lundgren, S.E., Scully, A.L., Thomas, J.B. Nature (1995) [Pubmed]
  25. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Cáceres, J.F., Stamm, S., Helfman, D.M., Krainer, A.R. Science (1994) [Pubmed]
  26. Sequence-specific DNA binding of the proto-oncoprotein ets-1 defines a transcriptional activator sequence within the long terminal repeat of the Moloney murine sarcoma virus. Gunther, C.V., Nye, J.A., Bryner, R.S., Graves, B.J. Genes Dev. (1990) [Pubmed]
  27. Molecular interactions of steroid hormone receptor with its enhancer element: evidence for receptor dimer formation. Tsai, S.Y., Carlstedt-Duke, J., Weigel, N.L., Dahlman, K., Gustafsson, J.A., Tsai, M.J., O'Malley, B.W. Cell (1988) [Pubmed]
  28. SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene. Yokoyama, C., Wang, X., Briggs, M.R., Admon, A., Wu, J., Hua, X., Goldstein, J.L., Brown, M.S. Cell (1993) [Pubmed]
  29. Reduced transcriptional regulatory competence of the androgen receptor in X-linked spinal and bulbar muscular atrophy. Mhatre, A.N., Trifiro, M.A., Kaufman, M., Kazemi-Esfarjani, P., Figlewicz, D., Rouleau, G., Pinsky, L. Nat. Genet. (1993) [Pubmed]
  30. Histone deacetylase activity is required for full transcriptional repression by mSin3A. Hassig, C.A., Fleischer, T.C., Billin, A.N., Schreiber, S.L., Ayer, D.E. Cell (1997) [Pubmed]
  31. Identification of a second human retinoic acid receptor. Brand, N., Petkovich, M., Krust, A., Chambon, P., de Thé, H., Marchio, A., Tiollais, P., Dejean, A. Nature (1988) [Pubmed]
  32. Steroid hormone receptors compete for factors that mediate their enhancer function. Meyer, M.E., Gronemeyer, H., Turcotte, B., Bocquel, M.T., Tasset, D., Chambon, P. Cell (1989) [Pubmed]
  33. RNA-mediated recombination in S. cerevisiae. Derr, L.K., Strathern, J.N., Garfinkel, D.J. Cell (1991) [Pubmed]
  34. A potential positive feedback loop controlling CLN1 and CLN2 gene expression at the start of the yeast cell cycle. Cross, F.R., Tinkelenberg, A.H. Cell (1991) [Pubmed]
  35. Identification and characterization of an IkappaB kinase. Régnier, C.H., Song, H.Y., Gao, X., Goeddel, D.V., Cao, Z., Rothe, M. Cell (1997) [Pubmed]
  36. Synpolydactyly in mice with a targeted deficiency in the HoxD complex. Zákány, J., Duboule, D. Nature (1996) [Pubmed]
  37. The gene teashirt is required for the development of Drosophila embryonic trunk segments and encodes a protein with widely spaced zinc finger motifs. Fasano, L., Röder, L., Coré, N., Alexandre, E., Vola, C., Jacq, B., Kerridge, S. Cell (1991) [Pubmed]
  38. Pheromone-dependent phosphorylation of the yeast STE12 protein correlates with transcriptional activation. Song, D., Dolan, J.W., Yuan, Y.L., Fields, S. Genes Dev. (1991) [Pubmed]
  39. Activation of cancer-specific gene expression by the survivin promoter. Bao, R., Connolly, D.C., Murphy, M., Green, J., Weinstein, J.K., Pisarcik, D.A., Hamilton, T.C. J. Natl. Cancer Inst. (2002) [Pubmed]
  40. Interaction between glucocorticoids and beta2 agonists on bronchial airway smooth muscle cells through synchronised cellular signalling. Roth, M., Johnson, P.R., Rüdiger, J.J., King, G.G., Ge, Q., Burgess, J.K., Anderson, G., Tamm, M., Black, J.L. Lancet (2002) [Pubmed]
  41. Transcriptional regulation of proliferin gene expression in response to serum in transfected mouse cells. Linzer, D.I., Mordacq, J.C. EMBO J. (1987) [Pubmed]
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