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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
MeSH Review

Genes, Reporter

 
 
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Disease relevance of Genes, Reporter

 

Psychiatry related information on Genes, Reporter

 

High impact information on Genes, Reporter

  • Reporter-gene studies using a minimal PTF1A deletion mutant indicate that the deleted region defines a new domain that is crucial for the function of this protein [7].
  • We used a targeted enhancer-trap approach to identify a DNA segment capable of directing reporter gene expression in both digits and CNS, following Lnp, Evx2, and Hoxd-specific patterns [8].
  • This sequence element bound to p53 and conferred p53-dependent inducibility on a heterologous reporter gene [9].
  • Luciferase reporter gene assays show that CLOCK-BMAL1 heterodimers act through an E box enhancer in the vasopressin gene to activate transcription; this activation can be inhibited by the mPER and mTIM proteins [10].
  • Furthermore, ectopic expression of Sox9 trans-activates both a COL2A1-driven reporter gene and the endogenous Col2a1 gene in transgenic mice [11].
 

Chemical compound and disease context of Genes, Reporter

 

Biological context of Genes, Reporter

 

Anatomical context of Genes, Reporter

 

Associations of Genes, Reporter with chemical compounds

  • A steroid hormone responsive element (GRE/PRE), sufficient to confer glucocorticoid and progesterone inducibility when linked to a reporter gene, was used in band-shift assays to examine its molecular interactions with steroid hormone receptors [27].
  • Overexpression of SREBP-1 activates transcription of reporter genes containing SRE-1 in the absence (15-fold) and presence (90-fold) of sterols, abolishing sterol regulation [28].
  • We have found that a polyglutamine (Gln) expanded AR transactivates an androgen-responsive reporter gene subnormally [29].
  • The mSin3A immunocomplexes possess histone deacetylase activity that is sensitive to the specific deacetylase inhibitor trapoxin. mSin3A-targeted repression of a reporter gene is reduced by trapoxin treatment, suggesting that histone deacetylation mediates transcriptional repression through Mad-Max-mSin3A multimeric complexes [30].
  • Here we show that retinoic acid (RA) at physiological concentrations is effective in inducing the expression of this reporter gene by the hap-ER chimaeric receptor [31].
 

Gene context of Genes, Reporter

  • Both the N-terminal A/B region and the hormone binding domain of ER were involved in this inhibition, which was antagonized by antiestrogens and did not appear to involve direct interaction between ER and either reporter gene or PR [32].
  • We used a HIS3 reporter gene to show that RNA-mediated recombination occurs in yeast [33].
  • An internally deleted nonfunctional cln2 gene was used as a reporter gene to demonstrate that in the absence of mating pheromone, efficient expression of cln2 mRNA requires both an active CDC28 gene and at least one functional CLN gene. mRNA from a nonfunctional cln1 gene was regulated similarly [34].
  • Overexpression of CHUK activates a NF-kappaB-dependent reporter gene [35].
  • A Hoxd-11/lacz reporter gene replaced the deleted region in order to monitor the effect of this triple inactivation at the cellular level [36].
 

Analytical, diagnostic and therapeutic context of Genes, Reporter

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