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Gene Review

WWS  -  Wieacker-Wolff syndrome

Homo sapiens

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High impact information on WWS

  • Localization of the gene for Wieacker-Wolff syndrome in the pericentromeric region of the X chromosome [1].
  • The most common diagnoses in order of decreasing frequency will probably prove to be WWS, MDS, and ILS [2].
  • The association of MMS and protein C deficiency was first reported in this cohort of patients, whereas the association of the syndrome with WWS and AOS has not, hitherto, been described [3].

Analytical, diagnostic and therapeutic context of WWS


  1. Localization of the gene for Wieacker-Wolff syndrome in the pericentromeric region of the X chromosome. Kloos, D.U., Jakubiczka, S., Wienker, T., Wolff, G., Wieacker, P. Hum. Genet. (1997) [Pubmed]
  2. The neurogenetics of lissencephaly. Dobyns, W.B. Neurologic clinics. (1989) [Pubmed]
  3. Moyamoya syndrome as a risk factor for stroke in Saudi children. Novel and usual associations. Salih, M.A., Murshid, W.R., Al-Salman, M.M., Abdel-Gader, A.G., Al-Jarallah, A.A., Alorainy, I.A., Hassan, H.H., Kentab, A.Y., Van Maldergem, L., Othman, S.A., El-Desouki, M.I., Elgamal, E.A. Saudi medical journal. (2006) [Pubmed]
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