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Gene Review:

GDAP1L1 - ganglioside induced differentiation...

Homo sapiens

Synonyms: GDAP1-L1, Ganglioside-induced differentiation-associated protein 1-like 1, dJ881L22.1, dJ995J12.1.1

Shield, A.J. et al., Marco, A. et al.

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High impact information on GDAP1L1

The human genome contains a paralog of GDAP1 called GDAP1L1 [1].
This protein, and its paralogue GDAP1L1, appear to be structurally related to the cytosolic glutathione S-transferases (GST) including an N-terminal thioredoxin fold domain with conserved active site residues [2].

Biological context of GDAP1L1

Using comparative genomics, we show that orthologs of GDAP1 and GDAP1L1 are found in mammals, birds, amphibians, and fishes [1].

Analytical, diagnostic and therapeutic context of GDAP1L1

To further characterise their structure and function we purified recombinant human GDAP1 and GDAP1L1 proteins using bacterial expression and immobilised metal affinity chromatography [2].

References

Evolutionary and structural analyses of GDAP1, involved in Charcot-Marie-Tooth disease, characterize a novel class of glutathione transferase-related genes. Marco, A., Cuesta, A., Pedrola, L., Palau, F., Marín, I. Mol. Biol. Evol. (2004) [Pubmed]
Functional characterisation of ganglioside-induced differentiation-associated protein 1 as a glutathione transferase. Shield, A.J., Murray, T.P., Board, P.G. Biochem. Biophys. Res. Commun. (2006) [Pubmed]

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