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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

CRELD2  -  cysteine-rich with EGF-like domains 2

Homo sapiens

Synonyms: Cysteine-rich with EGF-like domain protein 2, MGC11256, UNQ185/PRO211
 
 
 
 
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High impact information on CRELD2

  • The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits [1].
  • Finally, CRELD2 decreases the functional expression and impairs membrane transport of alpha4beta2 nAChRs in Xenopus leavis oocytes, without affecting alpha3beta4 and alpha7 nAChR expression [1].
 

Analytical, diagnostic and therapeutic context of CRELD2

  • Immunohistochemistry experiments demonstrated the presence of CRELD2 in the rat brain at sites where alpha4beta2 receptors have been previously detected [1].

References

  1. The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits. Ortiz, J.A., Castillo, M., del Toro, E.D., Mulet, J., Gerber, S., Valor, L.M., Sala, S., Sala, F., Gutiérrez, L.M., Criado, M. J. Neurochem. (2005) [Pubmed]
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