The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

DCSTAMP  -  dendrocyte expressed seven transmembrane...

Homo sapiens

Synonyms: DC-STAMP, Dendritic cell-specific transmembrane protein, Dendrocyte-expressed seven transmembrane protein, FIND, IL-four-induced protein, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

High impact information on TM7SF4 [1]

TM7SF4 (also known as dendritic cell-specific transmembrane protein or DC-STAMP) is expressed in dendritic cells (DCs), the professional antigen-presenting cells of our immune system [1]. TM7SF4 is localized to the endoplasmic reticulum [2], but upon encountering danger signals that evoke innate immune responses, it translocates to the Golgi. This process is regulated by OS9, a protein involved in ER-to-Golgi transport [3] . TM7SF4 also binds to an ER-resident transcription factor (CREB3, also known as LUMAN), which needs to be transported to the Golgi to be activated in a process called regulated intramembrane proteolysis. Although the role of TM7SF4 is not exactly known, it is likely an important regulator of CREB3. Intriguingly, OS9 and CREB3 can also interact with each other, suggesting that TM7SF4, OS9 and CREB consist in a complex in the ER that dissociates into OS9 and TM7SF4/CREB3 upon triggering of innate immune signaling. This ultimately leads to the production of active, nuclear CREB3, which drives or represses gene expression and presumably modulates innate immune responses [4].




  1. DC-STAMP, a novel multimembrane-spanning molecule preferentially expressed by dendritic cells. Hartgers, F.C., Vissers, J.L., Looman, M.W., van Zoelen, C., Huffine, C., Figdor, C.G., Adema, G.J. Eur. J. Immunol. (2000) [Pubmed]
  2. The dendritic cell-derived protein DC-STAMP is highly conserved and localizes to the endoplasmic reticulum. Eleveld-Trancikova, D., Triantis, V., Moulin, V., Looman, M.W., Wijers, M., Fransen, J.A., Lemckert, A.A., Havenga, M.J., Figdor, C.G., Janssen, R.A., Adema, G.J. J. Leukoc. Biol. (2005) [Pubmed]
  3. OS9 interacts with DC-STAMP and modulates its intracellular localization in response to TLR ligation. Jansen, B.J., Eleveld-Trancikova, D., Sanecka, A., van Hout-Kuijer, M., Hendriks, I.A., Looman, M.G., Leusen, J.H., Adema, G.J. Mol. Immunol. (2009) [Pubmed]
  4. DC-STAMP interacts with ER-resident transcription factor LUMAN which becomes activated during DC maturation. Eleveld-Trancikova, D., Sanecka, A., van Hout-Kuijer, M.A., Looman, M.W., Hendriks, I.A., Jansen, B.J., Adema, G.J. Mol. Immunol. (2010) [Pubmed]
WikiGenes - Universities