The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Dendritic Cells

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Dendritic Cells


Psychiatry related information on Dendritic Cells


High impact information on Dendritic Cells

  • PTX3 is produced by a variety of cells and tissues, most notably dendritic cells and macrophages, in response to Toll-like receptor (TLR) engagement and inflammatory cytokines [8].
  • In the design and conduct of such trials, important considerations include antigen selection, methods for introducing the antigen into MHC class I and II processing pathways, methods for isolating and activating dendritic cells, and route of administration [9].
  • The regulation of chemokine receptor expression during development and following cell activation explains the complex migratory pathways taken by dendritic cells, T and B lymphocytes, providing new insights into the mechanisms that control priming, effector function, and memory responses [10].
  • In addition several new mediators of control have emerged, including IL-18, the intriguing Th2-selective T1/ST2 product, and heterogeneity in dendritic cells capable of directing cytokine-independent Th development [11].
  • Thymic epithelial cells, activated monocytes, and dendritic cells express CD40 antigen which may be involved in an enhanced cytokine production by these cells, allowing an amplification of T cell proliferation [12].

Chemical compound and disease context of Dendritic Cells


Biological context of Dendritic Cells


Anatomical context of Dendritic Cells


Associations of Dendritic Cells with chemical compounds


Gene context of Dendritic Cells

  • Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7 [31].
  • Ptx3 binds selected microbial agents, including conidia of Aspergillus fumigatus, and we found that susceptibility of Ptx3-null mice was associated with defective recognition of conidia by alveolar macrophages and dendritic cells, as well as inappropriate induction of an adaptive type 2 response [32].
  • Human beta-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells [33].
  • These same residues were responsible for the c-Rel requirement for Il12a induction in dendritic cells, and in both instances, no evidence of c-Rel-specific coactivator interactions was found [34].
  • While the pivotal role of CIITA for MHC-II gene transcription is supported by the essential absence of MHC-II molecules in CIITA-deficient mice, we demonstrate here that RFX5-/- mice retain expression of MHC-II in thymic medulla, mature dendritic cells, and activated B cells [35].

Analytical, diagnostic and therapeutic context of Dendritic Cells


  1. A variant in the CD209 promoter is associated with severity of dengue disease. Sakuntabhai, A., Turbpaiboon, C., Casadémont, I., Chuansumrit, A., Lowhnoo, T., Kajaste-Rudnitski, A., Kalayanarooj, S.M., Tangnararatchakit, K., Tangthawornchaikul, N., Vasanawathana, S., Chaiyaratana, W., Yenchitsomanus, P.T., Suriyaphol, P., Avirutnan, P., Chokephaibulkit, K., Matsuda, F., Yoksan, S., Jacob, Y., Lathrop, G.M., Malasit, P., Desprès, P., Julier, C. Nat. Genet. (2005) [Pubmed]
  2. Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity. Mayordomo, J.I., Zorina, T., Storkus, W.J., Zitvogel, L., Celluzzi, C., Falo, L.D., Melief, C.J., Ildstad, S.T., Kast, W.M., Deleo, A.B. Nat. Med. (1995) [Pubmed]
  3. Interleukin-4 acts at the locus of the antigen-presenting dendritic cell to counter-regulate cytotoxic CD8+ T-cell responses. King, C., Mueller Hoenger, R., Malo Cleary, M., Murali-Krishna, K., Ahmed, R., King, E., Sarvetnick, N. Nat. Med. (2001) [Pubmed]
  4. Vascular endothelial growth factor receptor-3 mediates induction of corneal alloimmunity. Chen, L., Hamrah, P., Cursiefen, C., Zhang, Q., Pytowski, B., Streilein, J.W., Dana, M.R. Nat. Med. (2004) [Pubmed]
  5. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells. Krutzik, S.R., Tan, B., Li, H., Ochoa, M.T., Liu, P.T., Sharfstein, S.E., Graeber, T.G., Sieling, P.A., Liu, Y.J., Rea, T.H., Bloom, B.R., Modlin, R.L. Nat. Med. (2005) [Pubmed]
  6. Monocyte-derived dendritic cells in bipolar disorder. Knijff, E.M., Ruwhof, C., de Wit, H.J., Kupka, R.W., Vonk, R., Akkerhuis, G.W., Nolen, W.A., Drexhage, H.A. Biol. Psychiatry (2006) [Pubmed]
  7. Postnatal development of dendritic spines on olfactory bulb granule cells in rats. Matsutani, S., Yamamoto, N. J. Comp. Neurol. (2004) [Pubmed]
  8. Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility. Garlanda, C., Bottazzi, B., Bastone, A., Mantovani, A. Annu. Rev. Immunol. (2005) [Pubmed]
  9. Dendritic cells in cancer immunotherapy. Fong, L., Engleman, E.G. Annu. Rev. Immunol. (2000) [Pubmed]
  10. The role of chemokine receptors in primary, effector, and memory immune responses. Sallusto, F., Mackay, C.R., Lanzavecchia, A. Annu. Rev. Immunol. (2000) [Pubmed]
  11. Signaling and transcription in T helper development. Murphy, K.M., Ouyang, W., Farrar, J.D., Yang, J., Ranganath, S., Asnagli, H., Afkarian, M., Murphy, T.L. Annu. Rev. Immunol. (2000) [Pubmed]
  12. The CD40 antigen and its ligand. Banchereau, J., Bazan, F., Blanchard, D., Brière, F., Galizzi, J.P., van Kooten, C., Liu, Y.J., Rousset, F., Saeland, S. Annu. Rev. Immunol. (1994) [Pubmed]
  13. DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Kwon, D.S., Gregorio, G., Bitton, N., Hendrickson, W.A., Littman, D.R. Immunity (2002) [Pubmed]
  14. Virulent Coxiella burnetii does not activate human dendritic cells: role of lipopolysaccharide as a shielding molecule. Shannon, J.G., Howe, D., Heinzen, R.A. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  15. Imatinib and plasmacytoid dendritic cell function in patients with chronic myeloid leukemia. Mohty, M., Jourdan, E., Mami, N.B., Vey, N., Damaj, G., Blaise, D., Isnardon, D., Olive, D., Gaugler, B. Blood (2004) [Pubmed]
  16. Nitric oxide confers therapeutic activity to dendritic cells in a mouse model of melanoma. Perrotta, C., Falcone, S., Capobianco, A., Camporeale, A., Sciorati, C., De Palma, C., Pisconti, A., Rovere-Querini, P., Bellone, M., Manfredi, A.A., Clementi, E. Cancer Res. (2004) [Pubmed]
  17. Chlamydia Infection Induces ICOS Ligand-Expressing and IL-10-Producing Dendritic Cells That Can Inhibit Airway Inflammation and Mucus Overproduction Elicited by Allergen Challenge in BALB/c Mice. Han, X., Wang, S., Fan, Y., Yang, J., Jiao, L., Qiu, H., Yang, X. J. Immunol. (2006) [Pubmed]
  18. Developmental control of endocytosis in dendritic cells by Cdc42. Garrett, W.S., Chen, L.M., Kroschewski, R., Ebersold, M., Turley, S., Trombetta, S., Galán, J.E., Mellman, I. Cell (2000) [Pubmed]
  19. The receptor DEC-205 expressed by dendritic cells and thymic epithelial cells is involved in antigen processing. Jiang, W., Swiggard, W.J., Heufler, C., Peng, M., Mirza, A., Steinman, R.M., Nussenzweig, M.C. Nature (1995) [Pubmed]
  20. Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand. Kong, Y.Y., Feige, U., Sarosi, I., Bolon, B., Tafuri, A., Morony, S., Capparelli, C., Li, J., Elliott, R., McCabe, S., Wong, T., Campagnuolo, G., Moran, E., Bogoch, E.R., Van, G., Nguyen, L.T., Ohashi, P.S., Lacey, D.L., Fish, E., Boyle, W.J., Penninger, J.M. Nature (1999) [Pubmed]
  21. The dendritic cell system and its role in immunogenicity. Steinman, R.M. Annu. Rev. Immunol. (1991) [Pubmed]
  22. A novel dendritic cell subset involved in tumor immunosurveillance. Taieb, J., Chaput, N., Ménard, C., Apetoh, L., Ullrich, E., Bonmort, M., Péquignot, M., Casares, N., Terme, M., Flament, C., Opolon, P., Lecluse, Y., Métivier, D., Tomasello, E., Vivier, E., Ghiringhelli, F., Martin, F., Klatzmann, D., Poynard, T., Tursz, T., Raposo, G., Yagita, H., Ryffel, B., Kroemer, G., Zitvogel, L. Nat. Med. (2006) [Pubmed]
  23. Therapy of human tumors in NOD/SCID mice with patient-derived reactivated memory T cells from bone marrow. Feuerer, M., Beckhove, P., Bai, L., Solomayer, E.F., Bastert, G., Diel, I.J., Pedain, C., Oberniedermayr, M., Schirrmacher, V., Umansky, V. Nat. Med. (2001) [Pubmed]
  24. GM-CSF and TNF-alpha cooperate in the generation of dendritic Langerhans cells. Caux, C., Dezutter-Dambuyant, C., Schmitt, D., Banchereau, J. Nature (1992) [Pubmed]
  25. Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Wang, T., Niu, G., Kortylewski, M., Burdelya, L., Shain, K., Zhang, S., Bhattacharya, R., Gabrilovich, D., Heller, R., Coppola, D., Dalton, W., Jove, R., Pardoll, D., Yu, H. Nat. Med. (2004) [Pubmed]
  26. Dendritic cell progenitor is transformed by a conditional v-Rel estrogen receptor fusion protein v-RelER. Boehmelt, G., Madruga, J., Dörfler, P., Briegel, K., Schwarz, H., Enrietto, P.J., Zenke, M. Cell (1995) [Pubmed]
  27. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Mazmanian, S.K., Liu, C.H., Tzianabos, A.O., Kasper, D.L. Cell (2005) [Pubmed]
  28. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Yamamoto, M., Sato, S., Hemmi, H., Sanjo, H., Uematsu, S., Kaisho, T., Hoshino, K., Takeuchi, O., Kobayashi, M., Fujita, T., Takeda, K., Akira, S. Nature (2002) [Pubmed]
  29. Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity. Akbari, O., Freeman, G.J., Meyer, E.H., Greenfield, E.A., Chang, T.T., Sharpe, A.H., Berry, G., DeKruyff, R.H., Umetsu, D.T. Nat. Med. (2002) [Pubmed]
  30. Anti-inflammatory actions of lipoxin A4 and aspirin-triggered lipoxin are SOCS-2 dependent. Machado, F.S., Johndrow, J.E., Esper, L., Dias, A., Bafica, A., Serhan, C.N., Aliberti, J. Nat. Med. (2006) [Pubmed]
  31. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Hornung, V., Guenthner-Biller, M., Bourquin, C., Ablasser, A., Schlee, M., Uematsu, S., Noronha, A., Manoharan, M., Akira, S., de Fougerolles, A., Endres, S., Hartmann, G. Nat. Med. (2005) [Pubmed]
  32. Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Garlanda, C., Hirsch, E., Bozza, S., Salustri, A., De Acetis, M., Nota, R., Maccagno, A., Riva, F., Bottazzi, B., Peri, G., Doni, A., Vago, L., Botto, M., De Santis, R., Carminati, P., Siracusa, G., Altruda, F., Vecchi, A., Romani, L., Mantovani, A. Nature (2002) [Pubmed]
  33. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Yang, D., Chertov, O., Bykovskaia, S.N., Chen, Q., Buffo, M.J., Shogan, J., Anderson, M., Schröder, J.M., Wang, J.M., Howard, O.M., Oppenheim, J.J. Science (1999) [Pubmed]
  34. A c-Rel subdomain responsible for enhanced DNA-binding affinity and selective gene activation. Sanjabi, S., Williams, K.J., Saccani, S., Zhou, L., Hoffmann, A., Ghosh, G., Gerondakis, S., Natoli, G., Smale, S.T. Genes Dev. (2005) [Pubmed]
  35. Residual MHC class II expression on mature dendritic cells and activated B cells in RFX5-deficient mice. Clausen, B.E., Waldburger, J.M., Schwenk, F., Barras, E., Mach, B., Rajewsky, K., Förster, I., Reith, W. Immunity (1998) [Pubmed]
  36. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Anderson, D.M., Maraskovsky, E., Billingsley, W.L., Dougall, W.C., Tometsko, M.E., Roux, E.R., Teepe, M.C., DuBose, R.F., Cosman, D., Galibert, L. Nature (1997) [Pubmed]
  37. Induction of antigen-specific immunosuppression by CD95L cDNA-transfected 'killer' dendritic cells. Matsue, H., Matsue, K., Walters, M., Okumura, K., Yagita, H., Takashima, A. Nat. Med. (1999) [Pubmed]
  38. DNA vaccination: transfection and activation of dendritic cells as key events for immunity. Akbari, O., Panjwani, N., Garcia, S., Tascon, R., Lowrie, D., Stockinger, B. J. Exp. Med. (1999) [Pubmed]
  39. A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells. Bouchon, A., Hernández-Munain, C., Cella, M., Colonna, M. J. Exp. Med. (2001) [Pubmed]
  40. Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells. Mueller, C.G., Rissoan, M.C., Salinas, B., Ait-Yahia, S., Ravel, O., Bridon, J.M., Briere, F., Lebecque, S., Liu, Y.J. J. Exp. Med. (1997) [Pubmed]
WikiGenes - Universities