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Gene Review:

LCFS2 - Lynch cancer family syndrome II

Homo sapiens

This record was replaced with 4436.

De Felice, C. et al.

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Disease relevance of LCFS2

BACKGROUND: Hereditary non-polyposis colorectal cancer (HNPCC) (Lynch cancer family syndrome I (LCFS1) and II (LCFS2)) is one of the most common hereditary cancer disorders [1].

High impact information on LCFS2

The vascular networks of LCFS2 gene carriers showed higher complexity at the smaller scale (D (1-15): 1.59 (0.12) v 1.47 (0.07); p=0.034), and higher destructured randomness (L-Z: 0.85 (0.11) v 0.73 (0.05); p=0.013) than those of non-carriers [1].

References

Abnormal vascular network complexity: a new phenotypic marker in hereditary non-polyposis colorectal cancer syndrome. De Felice, C., Latini, G., Bianciardi, G., Parrini, S., Fadda, G.M., Marini, M., Laurini, R.N., Kopotic, R.J. Gut (2003) [Pubmed]

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