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Gene Review

Il23a  -  interleukin 23, alpha subunit p19

Mus musculus

Synonyms: IL-23, IL-23 subunit alpha, IL-23-A, IL-23p19, Interleukin-23 subunit alpha, ...
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Disease relevance of Il23a

  • We have analyzed the role of IL-12 versus IL-23 in two models of Helicobacter hepaticus-triggered T cell-dependent colitis, one involving anti-IL-10R monoclonal antibody treatment of infected T cell-sufficient hosts, and the other involving CD4+ T cell transfer into infected Rag-/- recipients [1].

Regulatory relationships of Il23a

  • Co-transfection of c-Jun and ATF2 synergistically induced p19 promoter activation, and c-Jun and ATF2 formed a protein complex, demonstrated by co-immunoprecipitation [2].

Other interactions of Il23a

  • A critical target of IL-23 is a unique subset of tissue-homing memory T cells, which are specifically activated by IL-23 to produce the proinflammatory mediators IL-17 and IL-6 [3].


  1. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. Kullberg, M.C., Jankovic, D., Feng, C.G., Hue, S., Gorelick, P.L., McKenzie, B.S., Cua, D.J., Powrie, F., Cheever, A.W., Maloy, K.J., Sher, A. J. Exp. Med. (2006) [Pubmed]
  2. AP-1 activated by toll-like receptors regulates expression of IL-23 p19. Liu, W., Ouyang, X., Yang, J., Liu, J., Li, Q., Gu, Y., Fukata, M., Lin, T., He, J.C., Abreu, M., Unkeless, J.C., Mayer, L., Xiong, H. J. Biol. Chem. (2009) [Pubmed]
  3. IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6. Yen, D., Cheung, J., Scheerens, H., Poulet, F., McClanahan, T., McKenzie, B., Kleinschek, M.A., Owyang, A., Mattson, J., Blumenschein, W., Murphy, E., Sathe, M., Cua, D.J., Kastelein, R.A., Rennick, D. J. Clin. Invest. (2006) [Pubmed]
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